Alanazi Azhar M, Al-Rashoud Jinan R, Aljahani Jumanah M, Alotaibi Ahlam F, Althubaiti Alaa M, Kojan Suleiman M, Aljumah Mohammed A, Abulaban Ahmad A
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
Neurosciences (Riyadh). 2019 Jul;24(3):168-175. doi: 10.17712/nsj.2019.3.20180034.
To assess the outcome and impact of multiple sclerosis (MS) using validated Arabic versions of the Barthel index (BI) multiple sclerosis impact scale (MSIS-29), the modified Rankin scale (mRS), and the expanded disability status scale (EDSS).
A cross-sectional study conducted at King Abdulaziz Medical City in Riyadh, Kingdom of Saudi Arabia, during July-November 2017. All Saudi adult patients diagnosed with MS between 2000-2016 (269 patients) were included. Patients were contacted via phone calls and were assessed using a newly developed and validated multi-component questionnaire that included demographic data, disease course, and Arabic versions of the scales RESULTS: Out of 269 patients, 210 (78.2%) responded. The average patient age was 37.44+/-10.3 years. The majority were females (69.5%). Only, 51 (24.3%) patients reported worsening conditions. Annually, the average relapse rate was 2.28+/-1.91. In regard to patient outcomes, 120 (57.1%) showed no significant disability in mRS, 146 (69.5%) were ambulatory without aid in EDSS, and 185 (89.4%) were independent in BI scores. The average MSIS-29-PHYS score was 33.6+/-27.6 and MSIS-29-PSYCH score was 38.2+/-25.8. Modified Rankin scale and EDSS were significantly associated with the current use of disease-modifying therapy (DMT). Modified Rankin scale was negatively associated with delayed diagnosis. Barthel index showed significant association with medication compliance and the absence of attacks.
Majority of patients had a favorable outcome that was linked with the use of DMT, compliance, early diagnosis, and absence of attacks.
使用经过验证的阿拉伯语版巴氏指数（BI）、多发性硬化症影响量表（MSIS - 29）、改良Rankin量表（mRS）和扩展残疾状态量表（EDSS）来评估多发性硬化症（MS）的结局和影响。
2017年7月至11月在沙特阿拉伯王国利雅得的阿卜杜勒阿齐兹国王医疗城进行了一项横断面研究。纳入了2000年至2016年间诊断为MS的所有沙特成年患者（269例患者）。通过电话联系患者，并使用新开发并经过验证的多成分问卷进行评估，该问卷包括人口统计学数据、疾病病程以及量表的阿拉伯语版。结果：269例患者中，210例（78.2%）做出了回应。患者的平均年龄为37.44±10.3岁。大多数为女性（69.5%）。只有51例（24.3%）患者报告病情恶化。每年的平均复发率为2.28±1.91。关于患者结局，120例（57.1%）在mRS中显示无明显残疾，146例（69.5%）在EDSS中无需辅助即可行走，185例（89.4%）在BI评分中独立。MSIS - 29 - PHYS的平均评分为33.6±27.6，MSIS - 29 - PSYCH的平均评分为38.2±25.8。改良Rankin量表和EDSS与目前使用疾病修饰疗法（DMT）显著相关。改良Rankin量表与诊断延迟呈负相关。巴氏指数与药物依从性和无发作显著相关。
大多数患者有良好的结局，这与使用DMT、依从性、早期诊断和无发作有关。
