Moretta L, Mingari M C, Moretta A, Romanzi C A
Biomedicine. 1979 Feb;30(1):4-8.
Human T lymphocyte subpopulations can be identified on the basis of surface receptors for G or M immunoglobulins (TM and TG cells respectively). Isolated TM or TG cells can be analyzed in vitro for their morphology and their functional properties. In addition to unique characteristics observed in light and electron microscopy, TM and TG cells show a different pattern of responsiveness to PHA and alloantigens. The major functional difference so far observed concerns their interaction with B lymphocytes. TM cells provide help for the T-dependent responses of B lymphocytes to pokeweek mitogen (PWM), whereas TG cells suppress B lympohcyte activation in this in vitro system by inhibiting helper TM cells. Imbalances and/or functional alterations of TM and TG cells are present in various immunological disorders and are possibly involved in the pathogenesis of these diseases.
人类T淋巴细胞亚群可根据针对G或M免疫球蛋白的表面受体（分别为TM和TG细胞）来识别。分离出的TM或TG细胞可在体外分析其形态和功能特性。除了在光学和电子显微镜下观察到的独特特征外，TM和TG细胞对PHA和同种异体抗原表现出不同的反应模式。迄今为止观察到的主要功能差异涉及它们与B淋巴细胞的相互作用。TM细胞为B淋巴细胞对商陆丝裂原（PWM）的T细胞依赖性反应提供帮助，而TG细胞在该体外系统中通过抑制辅助性TM细胞来抑制B淋巴细胞的激活。TM和TG细胞的失衡和/或功能改变存在于各种免疫性疾病中，并可能参与这些疾病的发病机制。
