Goust J M, Hoffman P M, Pryjma J, Hogan E L, Fudenberg H H
Ann Neurol. 1980 Nov;8(5):526-33. doi: 10.1002/ana.410080510.
Imbalances in T cell subpopulations have been reported in multiple sclerosis (MS). In the present study of 31 MS patients, the percentage of T cells with Fc receptors for IgG (Tg) was found to be increased in patients with chronic progressive disease, and another T cell subset binding to the Raji B lymphoid cell line was decreased. An inverse correlation (r = -0.675; < 95% confidence limit) was found between these two subsets, suggesting that they vary inversely in MS. The mitogenic responses of MS mononuclear cells, isolated T cells, and recombinet T and non-T cells to the lectins phytohemagglutinin and pokeweek mitogen (PWM) did not differ from those of normal cells. However, more immunoglobulin (Ig)-producing cells were generated in a PWM-driven system with cells from MS patients than with cells from age-matched controls (p < 0.05). Autologous recombination of separated T and non-T cells did not significantly modify these results. T cells from MS patients added to B cells from normal controls exerted an effect that was related to their percentage of Tg cells; that is, values above 15% were associated with a suppression of Ig production, whereas for Tg values below 12%, a helper effect or no modification was observed. These results suggest that changes in T cell subsets in MS are related to changes in functional ability to modulate Ig production by normal B cells. However, MS B cells partly escape regulation by their own T cells, suggesting an associated B cell hyperactivity.
在多发性硬化症（MS）中已报道了T细胞亚群的失衡。在本项针对31例MS患者的研究中，发现慢性进展性疾病患者中具有IgG Fc受体（Tg）的T细胞百分比增加，而与Raji B淋巴细胞系结合的另一个T细胞亚群减少。在这两个亚群之间发现了负相关（r = -0.675；<95%置信限），表明它们在MS中呈相反变化。MS单核细胞、分离的T细胞以及重组T细胞和非T细胞对植物血凝素和商陆有丝分裂原（PWM）的促有丝分裂反应与正常细胞无异。然而，在PWM驱动的系统中，与年龄匹配的对照组细胞相比，MS患者的细胞产生了更多的免疫球蛋白（Ig）产生细胞（p < 0.05）。分离的T细胞和非T细胞的自体重组并未显著改变这些结果。将MS患者的T细胞添加到正常对照的B细胞中所产生的效应与其Tg细胞百分比相关；也就是说，高于15%的值与Ig产生的抑制有关，而对于低于12%的Tg值，则观察到辅助效应或无变化。这些结果表明，MS中T细胞亚群的变化与调节正常B细胞产生Ig的功能能力的变化有关。然而，MS B细胞部分逃避了自身T细胞的调节，提示存在相关的B细胞功能亢进。
