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肽分子在药物和化妆品中的应用选择。

Selected application of peptide molecules as pharmaceutical agents and in cosmeceuticals.

机构信息

Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Science, Shiraz, Iran.

出版信息

Expert Opin Biol Ther. 2019 Dec;19(12):1275-1287. doi: 10.1080/14712598.2019.1652592. Epub 2019 Aug 13.

DOI:10.1080/14712598.2019.1652592
PMID:31382850
Abstract

: Peptide molecules are being vastly investigated as an emerging class of therapeutic molecules in recent years. Currently, 60 peptides have been approved by the US Food and Drug Administration (FDA), and more would enter the market in near future. Peptides have already opened their ways into cosmeceutical and food industries as well.: Antibodies, vaccines, and antimicrobial agents are the major classes of therapeutic peptides. Additionally, peptides may be employed in drug development to support cell penetration or targeting. The interest in antimicrobial peptides is surging due to the increasing risk of antibiotic-resistant pathogens. Peptide vaccines with their significant advantages compared with traditional vaccines, are expected to find their place in coming years, especially for cancer, microbial and allergen-specific immunotherapy. The usage of peptides in cosmeceuticals is also growing rapidly.: Peptide synthesis has become accessible, and advances in peptide engineering, sequencing technologies, and structural bioinformatics have resulted in the rational designing of novel peptides. All these advancements would lead to the more prominent roles of peptides in the mentioned areas. In this review, we discuss applications of peptides in different fields including pharmaceuticals, cosmeceuticals, besides the critical factors in designing efficient peptide molecules.

摘要

近年来,肽分子作为一类新兴的治疗分子受到了广泛的研究。目前,美国食品和药物管理局(FDA)已经批准了 60 种肽,并且在不久的将来还会有更多的肽进入市场。肽已经在化妆品和食品行业开辟了道路:抗体、疫苗和抗菌剂是治疗肽的主要类别。此外,肽可用于药物开发,以支持细胞穿透或靶向。由于抗生素耐药性病原体的风险不断增加,抗菌肽的兴趣正在激增。与传统疫苗相比,肽疫苗具有显著优势,预计在未来几年将找到自己的位置,特别是在癌症、微生物和过敏原特异性免疫治疗方面。肽在化妆品中的应用也在迅速增长:肽合成已经变得可行,肽工程、测序技术和结构生物信息学的进步导致了新型肽的合理设计。所有这些进展都将使肽在上述领域发挥更突出的作用。在这篇综述中,我们讨论了肽在包括制药、化妆品在内的不同领域的应用,以及设计有效肽分子的关键因素。

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