Gedar Totuk Ozgun Melike, Yukselen Ayfer
Department of Ophthalmology, Bahcesehir University, Faculty of Medicine, Istanbul, Turkey.
Department of Pediatric Allergy and Immunology, Bahcesehir University, Faculty of Medicine, Istanbul, Turkey.
Saudi J Ophthalmol. 2019 Apr-Jun;33(2):180-182. doi: 10.1016/j.sjopt.2018.10.001. Epub 2018 Oct 10.
Azithromycin 1.5% ophthalmic solution (Azyter®, Thea Pharmaceuticals, Newcastle, UK) is an effective and well-tolerated option for the treatment of bacterial conjunctivitis and blepharitis, and has the advantage of a shorter treatment duration than other topical antibiotics. No acute allergic reaction has yet been reported in response to topical azithromycin eye drops. Here, we report two cases with unusual acute-type allergic reaction to topical azithromycin eye drops. A 63-year-old female patient and 67-year-old male patient treated for blepharitis with topical azithromycin 1.5% eye drops presented with epiphora, eyelid edema, chemosis, conjunctival injection, hyperemia, intensive papillary reaction, and rhinitis within 30 min of instillation. Upon cessation of the topical medication and administration of antiallergic therapy, both patients immediately showed dramatic improvement. Acute-type allergic reaction to topical azithromycin eye drops may be a rare side effect, but ophthalmologists should keep this possibility in mind and inform the patients about its potential occurrence.
1.5%阿奇霉素眼药水（Azyter®，西娅制药公司，英国纽卡斯尔）是治疗细菌性结膜炎和睑缘炎的一种有效且耐受性良好的选择，并且与其他局部用抗生素相比具有治疗时间较短的优势。尚未有关于局部用阿奇霉素眼药水引起急性过敏反应的报道。在此，我们报告两例局部用阿奇霉素眼药水引起不寻常急性过敏反应的病例。一名63岁女性患者和一名67岁男性患者使用1.5%阿奇霉素眼药水治疗睑缘炎，在滴眼药水后30分钟内出现流泪、眼睑水肿、球结膜水肿、结膜充血、睑结膜乳头反应强烈和鼻炎。停用局部用药并给予抗过敏治疗后，两名患者的症状均立即显著改善。局部用阿奇霉素眼药水引起的急性过敏反应可能是一种罕见的副作用，但眼科医生应牢记这种可能性，并告知患者其可能发生。
