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干细胞与整形外科学

Stem Cells and Plastic Surgery.

作者信息

Agrawal Nikhil A, Zavlin Dmitry, Louis Matthew R, Reece Edward M

机构信息

Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas.

Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, Houston, Texas.

出版信息

Semin Plast Surg. 2019 Aug;33(3):162-166. doi: 10.1055/s-0039-1693018. Epub 2019 Aug 2.

DOI:10.1055/s-0039-1693018
PMID:31384231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6680093/
Abstract

Pluripotent stem cells can help recreate a variety of different tissues. Stem cells are already in use in a variety of ways in the medical field but plastic surgeons have particular interest because of the constant need to produce additional tissue or mold existing tissue. More and more commercial products are being marketed with far-reaching goals and some with proven and promising results. In this article, the authors discuss the basic science behind stem cells and the theories on how they work. They then discuss some active uses of stem cells that should be understood by all plastic surgeons. The reader should then have an understanding and basis to evaluate new technologies and commercial products as they develop.

摘要

多能干细胞有助于重建各种不同的组织。干细胞已在医学领域以多种方式得到应用,但整形外科医生对此尤为感兴趣,因为他们一直需要制造额外的组织或重塑现有组织。越来越多的商业产品正以影响深远的目标进行营销,其中一些已取得了经证实且前景广阔的成果。在本文中,作者讨论了干细胞背后的基础科学以及它们的作用原理。然后,他们讨论了所有整形外科医生都应了解的干细胞的一些实际应用。读者随后应具备理解和评估新技术及商业产品发展情况的基础。

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本文引用的文献

1
A case-controlled study of the oncologic safety of fat grafting.脂肪移植肿瘤学安全性的病例对照研究。
Plast Reconstr Surg. 2015 May;135(5):1263-1275. doi: 10.1097/PRS.0000000000001151.
2
Modulating the stem cell niche for tissue regeneration.调节干细胞微环境以促进组织再生。
Nat Biotechnol. 2014 Aug;32(8):795-803. doi: 10.1038/nbt.2978.
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Comparative analysis of processing methods in fat grafting.脂肪移植中处理方法的比较分析。
Plast Reconstr Surg. 2014 Oct;134(4):675-683. doi: 10.1097/PRS.0000000000000524.
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Transcranial amelioration of inflammation and cell death after brain injury.经颅改善脑损伤后的炎症和细胞死亡。
Nature. 2014 Jan 9;505(7482):223-8. doi: 10.1038/nature12808. Epub 2013 Dec 8.
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A localized Wnt signal orients asymmetric stem cell division in vitro.局部化的 Wnt 信号在体外定向不对称的干细胞分裂。
Science. 2013 Mar 22;339(6126):1445-8. doi: 10.1126/science.1231077.
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Human adipose stem cells: current clinical applications.人脂肪干细胞:当前的临床应用。
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Trends Pharmacol Sci. 2012 Jul;33(7):405-12. doi: 10.1016/j.tips.2012.04.002. Epub 2012 May 25.
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How I treat patients who mobilize hematopoietic stem cells poorly.我是如何治疗造血干细胞动员不良的患者的。
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Burns. 2011 Sep;37(6):964-72. doi: 10.1016/j.burns.2011.03.011. Epub 2011 May 6.
10
Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1.成人表皮 Notch 活性通过上调 Jagged1 诱导 T 细胞和神经嵴衍生物在真皮中的积累。
Development. 2010 Nov;137(21):3569-79. doi: 10.1242/dev.050310.