Moustaki Margarita, Papadopoulos Othon, Verikokos Christos, Karypidis Dimitrios, Masud Dhalia, Kostakis Alkiviadis, Papastefanaki Florentia, Roubelakis Maria G, Perrea Despoina
Laboratory of Experimental Surgery and Surgical Research 'N.S. Christeas', Athens Medical School, 11527 Athens, Greece.
Plastic Surgery Department, Guy's and St Thomas' NHS Foundation Trust, SE1 9RT London, UK.
Exp Ther Med. 2017 Sep;14(3):2415-2423. doi: 10.3892/etm.2017.4811. Epub 2017 Jul 19.
Autologous fat is considered the ideal material for soft-tissue augmentation in plastic and reconstructive surgery. The primary drawback of autologous fat grafting is the high resorption rate. The isolation of mesenchymal stem cells from adipose tissue inevitably led to research focusing on the study of combined transplantation of autologous fat and adipose derived stem cells (ADSCs) and introduced the theory of 'cell-assisted lipotransfer'. Transplantation of ADSCs is a promising strategy, due to the high proliferative capacity of stem cells, their potential to induce paracrine signalling and ability to differentiate into adipocytes and vascular cells. The current study examined the literature for clinical and experimental studies on cell-assisted lipotransfer to assess the efficacy of this novel technique when compared with traditional fat grafting. A total of 30 studies were included in the present review. The current study demonstrates that cell-assisted lipotransfer has improved efficacy compared with conventional fat grafting. Despite relatively positive outcomes, further investigation is required to establish a consensus in cell-assisted lipotransfer.
自体脂肪被认为是整形和重建手术中软组织填充的理想材料。自体脂肪移植的主要缺点是吸收率高。从脂肪组织中分离间充质干细胞不可避免地促使研究聚焦于自体脂肪与脂肪来源干细胞（ADSCs）联合移植的研究，并引入了“细胞辅助脂肪移植”理论。由于干细胞具有高增殖能力、诱导旁分泌信号的潜力以及分化为脂肪细胞和血管细胞的能力，ADSCs移植是一种有前景的策略。本研究检索了关于细胞辅助脂肪移植的临床和实验研究文献，以评估这种新技术与传统脂肪移植相比的疗效。本综述共纳入30项研究。目前的研究表明，与传统脂肪移植相比，细胞辅助脂肪移植的疗效有所提高。尽管结果相对积极，但仍需要进一步研究以在细胞辅助脂肪移植方面达成共识。
