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炎症性肠病中的内镜检查:从指南到现实生活

Endoscopy in inflammatory bowel disease: from guidelines to real life.

作者信息

Negreanu Lucian, Voiosu Theodor, State Monica, Voiosu Andrei, Bengus Andreea, Mateescu Bogdan Radu

机构信息

University Hospital Bucharest, Gastroenterology Department, Splaiul Independentei Nr. 169, Sector 5, Bucharest, Bucuresti, Romania.

Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania.

出版信息

Therap Adv Gastroenterol. 2019 Jul 24;12:1756284819865153. doi: 10.1177/1756284819865153. eCollection 2019.

Abstract

Endoscopy has a central role in the management of inflammatory bowel disease (IBD), providing crucial data for diagnostic and therapeutic decisions, treating disease-related complications, and assisting in the early detection of dysplasia and prevention of colorectal cancer in the setting of IBD. Treatment targets have significantly shifted in IBD, focusing on achieving mucosal healing, a more meaningful endpoint than clinical remission. With the emergence of novel therapies, we aim to alter the course of the disease and prevent irreversible damage to the bowel. To that end, obtaining reliable and reproducible assessments of endoscopic disease activity has become an issue of great importance. Although several guidelines include recommendations regarding endoscopic surveillance in patients with long-standing IBD, there is an open debate regarding the best examination method and the appropriate follow-up intervals. Another important issue is whether surveillance guidelines are actually implemented in real-life practice and what is the preferred surveillance method among endoscopists. Significant changes have occurred in the endoscopic world with the development of new diagnostic and therapeutic modalities and their incorporation in everyday practice. We aimed to assess the real-life application of guideline recommendations regarding endoscopy in IBD patients and to review newly emerged data which might impact these recommendations in the near future.

摘要

内镜检查在炎症性肠病(IBD)的管理中发挥着核心作用,为诊断和治疗决策提供关键数据,治疗疾病相关并发症,并有助于在IBD背景下早期发现发育异常和预防结直肠癌。IBD的治疗目标已发生显著转变,重点是实现黏膜愈合,这是一个比临床缓解更有意义的终点。随着新型疗法的出现,我们旨在改变疾病进程并预防肠道的不可逆损伤。为此,获得可靠且可重复的内镜疾病活动评估已成为一个极为重要的问题。尽管有若干指南包含了关于长期IBD患者内镜监测的建议,但对于最佳检查方法和适当的随访间隔仍存在公开辩论。另一个重要问题是监测指南在实际临床实践中是否真正得到实施,以及内镜医师中首选的监测方法是什么。随着新的诊断和治疗方式的发展及其融入日常实践,内镜领域发生了重大变化。我们旨在评估IBD患者内镜检查指南建议的实际应用情况,并回顾可能在不久的将来影响这些建议的新出现的数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09d7/6657117/6b7432dad14c/10.1177_1756284819865153-fig1.jpg

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