Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain.
Instituto Investigación Biosanitaria, Granada, Spain.
Immunology. 2019 Nov;158(3):153-160. doi: 10.1111/imm.13103. Epub 2019 Aug 30.
Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of unknown etiology, although genetic and environmental factors appear to contribute to its pathogenesis. Specifically, infectious processes are associated with SLE onset and exacerbation. However, we are far from a complete understanding of the interactions between infectious agents and the host, explaining the interest in gathering updated scientific information on this topic. According to the literature, the pathogens most frequently associated with SLE are viruses, notably human endogenous retroviruses, Epstein-Barr virus, parvovirus B19, cytomegalovirus and human immunodeficiency virus type 1, alongside certain bacterial components that can also trigger activation of the immune system. The mechanisms underlying autoreactivity remain unclear but various explanations have been proposed, including immunological changes responsible for infectious processes or molecular mimicry between host structures and those of infectious agents.
系统性红斑狼疮（SLE）是一种病因不明的自身免疫性慢性炎症性疾病，尽管遗传和环境因素似乎有助于其发病机制。具体来说，感染过程与 SLE 的发病和加重有关。然而，我们远未完全了解感染因子与宿主之间的相互作用，这解释了人们对收集有关这一主题的最新科学信息的兴趣。根据文献，与 SLE 最常相关的病原体是病毒，特别是人类内源性逆转录病毒、EB 病毒、细小病毒 B19、巨细胞病毒和人类免疫缺陷病毒 1，以及某些细菌成分，这些成分也可以触发免疫系统的激活。自身反应性的机制尚不清楚，但提出了各种解释，包括负责感染过程的免疫变化或宿主结构与感染因子之间的分子模拟。
