提高姜黄素治疗胃癌疗效的策略。
Strategy for improved therapeutic efficiency of curcumin in the treatment of gastric cancer.
机构信息
BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 121 00 Prague 2, Czech Republic; Department of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Technická 5, 166 28 Prague 6, Czech Republic.
BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 121 00 Prague 2, Czech Republic.
出版信息
Biomed Pharmacother. 2019 Oct;118:109278. doi: 10.1016/j.biopha.2019.109278. Epub 2019 Aug 3.
Gastric cancer is a common oncological disease. Although enormous efforts have been expended, possible therapeutic modalities are still limited. For this reason, new therapeutic approaches and agents are highly requested and intensively developed. One strategy is the application of natural agents, such as curcumin, with proven anticancer effects and low toxicity for patients. Therefore, this review discusses the potential application of curcumin in the therapy of gastric cancer and its potential incorporation in therapeutic regimens. Because one of the largest impediments for widespread curcumin application is its limited bioavailability (caused mainly by its very low water solubility), studied strategies (drug delivery systems and curcumin derivatization) aimed to solve this obstacle are discussed in more detail.
胃癌是一种常见的肿瘤疾病。尽管已经付出了巨大的努力，但可能的治疗方法仍然有限。因此，人们强烈要求并积极开发新的治疗方法和药物。一种策略是应用天然药物，如姜黄素，它具有已被证实的抗癌作用和对患者的低毒性。因此，本综述讨论了姜黄素在胃癌治疗中的潜在应用及其在治疗方案中的潜在应用。由于姜黄素广泛应用的最大障碍之一是其生物利用度有限（主要是由于其极低的水溶性），因此本文更详细地讨论了旨在解决这一障碍的研究策略（药物传递系统和姜黄素衍生化）。
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