Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.
Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.
Biomed Pharmacother. 2019 Oct;118:109282. doi: 10.1016/j.biopha.2019.109282. Epub 2019 Aug 3.
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most common form of arthritis. The pathogenesis of OA is unclear, yet studies have shown that it is due to an imbalance between the synthesis and decomposition of chondrocytes, cell matrices and subchondral bone, which leads to the degeneration of articular cartilage. Currently, there are many therapies that can be used to treat OA, including the use of pulsed electromagnetic fields (PEMFs). PEMFs stimulate proliferation of chondrocytes and exert a protective effect on the catabolic environment. Furthermore, this technique is beneficial for subchondral trabecular bone microarchitecture and the prevention of subchondral bone loss, ultimately blocking the progression of OA. However, it is still unknown whether PEMFs could be used to treat OA in the clinic. Furthermore, the deeper signaling pathways underlying the mechanism by which PEMFs influence OA remain unclear.
骨关节炎（OA），以关节功能障碍和慢性残疾为特征，是最常见的关节炎形式。OA 的发病机制尚不清楚，但研究表明，它是由于软骨细胞、细胞基质和软骨下骨的合成和分解之间的失衡导致关节软骨退化。目前，有许多治疗方法可用于治疗 OA，包括使用脉冲电磁场（PEMFs）。PEMFs 可刺激软骨细胞增殖，并对分解代谢环境发挥保护作用。此外，该技术有利于软骨下小梁骨微结构和防止软骨下骨丢失，最终阻止 OA 的进展。然而，PEMFs 是否可用于临床治疗 OA 仍不清楚。此外，PEMFs 影响 OA 的机制的更深层次信号通路仍不清楚。
