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长链非编码 RNA MIR4435-2HG 在骨关节炎中表达下调，调节软骨细胞的增殖和凋亡。

LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis.

机构信息

Department of Orthopaedic Surgery, Tianjin Hospital, No.406 Jiefang South Road, Hexi, Tianjin City, 300211, People's Republic of China.

Department of Orthopaedic Surgery, Tianjin Haihe Hospital, 890 Jingu Road, Shuanggang Zhen, Jinnan, Tianjin, 300350, People's Republic of China.

出版信息

J Orthop Surg Res. 2019 Aug 6;14(1):247. doi: 10.1186/s13018-019-1278-7.

DOI:10.1186/s13018-019-1278-7
PMID:31387631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6683450/
Abstract

PURPOSE

MIR4435-2HG is an oncogenic lncRNA in gastric cancer and lung cancer. Our preliminary microarray data showed that MIR4435-2HG was downregulated in osteoarthritis plasma specimen, indicating the possible involvement of MIR4435-2HG in osteoarthritis.

RESULTS

MIR4435-2HG was downregulated in plasma of osteoarthritis than in plasma of healthy controls. Reduced levels of MIR4435-2HG expression effectively distinguished osteoarthritis patients from the control group. Expression levels of MIR4435-2HG increased after treatment. Overexpression of MIR4435-2HG promoted, while MIR4435-2HG knockdown inhibited the proliferation of chondrocytes. In contrast, MIR4435-2HG overexpression inhibited, while MIR4435-2HG knockdown promoted the apoptosis of chondrocytes.

CONCLUSION

MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis.

摘要

目的

MIR4435-2HG 是胃癌和肺癌中的致癌 lncRNA。我们的初步基因芯片数据显示，MIR4435-2HG 在骨关节炎血浆标本中下调，表明 MIR4435-2HG 可能参与骨关节炎。

结果

MIR4435-2HG 在骨关节炎患者的血浆中的表达水平低于健康对照组。MIR4435-2HG 表达水平的降低可有效区分骨关节炎患者和对照组。治疗后 MIR4435-2HG 的表达水平增加。MIR4435-2HG 的过表达促进，而 MIR4435-2HG 的敲低抑制软骨细胞的增殖。相反，MIR4435-2HG 的过表达抑制，而 MIR4435-2HG 的敲低促进软骨细胞的凋亡。

结论

MIR4435-2HG 在骨关节炎中下调，并调节软骨细胞的增殖和凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/7d28b1cfdd09/13018_2019_1278_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/e86b19c26a3e/13018_2019_1278_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/19988d3ddf87/13018_2019_1278_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/b3fe3857a9ab/13018_2019_1278_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/7d28b1cfdd09/13018_2019_1278_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/e86b19c26a3e/13018_2019_1278_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/19988d3ddf87/13018_2019_1278_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/b3fe3857a9ab/13018_2019_1278_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78aa/6683450/7d28b1cfdd09/13018_2019_1278_Fig4_HTML.jpg

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The combination of circulating long noncoding RNAs AK001058, INHBA-AS1, MIR4435-2HG, and CEBPA-AS1 fragments in plasma serve as diagnostic markers for gastric cancer.血浆中循环长链非编码RNA AK001058、INHBA-AS1、MIR4435-2HG和CEBPA-AS1片段的组合可作为胃癌的诊断标志物。
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