Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Rheumatology, University Hospital of Liège (CHULiege), Liège, Belgium.
Front Immunol. 2021 Nov 29;12:773171. doi: 10.3389/fimmu.2021.773171. eCollection 2021.
Osteoarthritis (OS) is the most frequent degenerative condition in the joints, disabling many adults. Several abnormalities in the articular cartilage, subchondral bone, synovial tissue, and meniscus have been detected in the course of OA. Destruction of articular cartilage, the formation of osteophytes, subchondral sclerosis, and hyperplasia of synovial tissue are hallmarks of OA. More recently, several investigations have underscored the regulatory roles of non-coding RNAs (ncRNAs) in OA development. Different classes of non-coding RNAs, including long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), have been reported to affect the development of OA. The expression level of these transcripts has also been used as diagnostic tools in OA. In the present article, we aimed at reporting the role of these transcripts in this process. We need to give a specific angle on the pathology to provide meaningful thoughts on it.
骨关节炎（OA）是关节最常见的退行性疾病，使许多成年人致残。在 OA 过程中已经检测到关节软骨、软骨下骨、滑膜组织和半月板的几种异常。关节软骨的破坏、骨赘的形成、软骨下硬化和滑膜组织的增生是 OA 的标志。最近，几项研究强调了非编码 RNA（ncRNA）在 OA 发展中的调节作用。不同类别的非编码 RNA，包括长链非编码 RNA（lncRNA）、microRNAs（miRNAs）和环状 RNA（circRNA），已被报道影响 OA 的发展。这些转录物的表达水平也被用作 OA 的诊断工具。在本文中，我们旨在报告这些转录物在这一过程中的作用。我们需要从特定的角度对病理学进行分析，以便对其进行有意义的思考。
