EFSA J. 2018 Feb 27;16(2):e05182. doi: 10.2903/j.efsa.2018.5182. eCollection 2018 Feb.
The data on antimicrobial resistance in zoonotic and indicator bacteria in 2016, submitted by 28 EU Member States (MSs), were jointly analysed by the EFSA and ECDC. Resistance in bacterial isolates of zoonotic and from humans, animals and food, and resistance in indicator as well as in meticillin-resistant from animals and food were addressed. 'Microbiological' resistance was assessed using epidemiological cut-off (ECOFF) values; for some countries, qualitative data on isolates from humans were interpreted in a way that corresponds closely to ECOFF-defined 'microbiological' resistance. In from humans, the occurrence of resistance to ampicillin, sulfonamides and tetracyclines was high, whereas resistance to third-generation cephalosporins was low. In and isolates from broilers, fattening turkeys and their meat, resistance to ampicillin, (fluoro)quinolones, tetracyclines and sulfonamides was frequently high, whereas resistance to third-generation cephalosporins was rare. The occurrence of ESBL-/AmpC producers was low in and from poultry and in from humans. The prevalence of ESBL-/AmpC-producing , assessed in poultry and its meat for the first time, showed marked variations among MSs. Fourteen presumptive carbapenemase-producing . were detected from broilers and its meat in two MSs. Resistance to colistin was observed at low levels in and from poultry and meat thereof and in from humans. In from humans, broilers and broiler meat, resistance to ciprofloxacin and tetracyclines was high to extremely high, whereas resistance to erythromycin was low to moderate. Combined resistance to critically important antimicrobials in isolates from both humans and animals was generally uncommon, but very high to extremely high multidrug resistance levels were observed in certain serovars. Specific serovars of (notably Kentucky) from both humans and animals exhibited high-level resistance to ciprofloxacin, in addition to findings of ESBL.
2016年,28个欧盟成员国提交的人畜共患病和指示菌的抗菌药物耐药性数据由欧洲食品安全局(EFSA)和欧洲疾病预防控制中心(ECDC)联合分析。研究涉及人畜共患病细菌分离株、来自人类、动物和食物的细菌分离株的耐药性,以及指示菌和动物及食物中耐甲氧西林细菌的耐药性。使用流行病学临界值(ECOFF)评估“微生物学”耐药性;对于一些国家,来自人类的分离株的定性数据以与ECOFF定义的“微生物学”耐药性密切对应的方式进行解释。在来自人类的大肠杆菌中,对氨苄西林、磺胺类药物和四环素的耐药性发生率较高,而对第三代头孢菌素的耐药性较低。在来自肉鸡、育肥火鸡及其肉的大肠杆菌和沙门氏菌分离株中,对氨苄西林、(氟)喹诺酮类、四环素和磺胺类药物的耐药性通常较高,而对第三代头孢菌素的耐药性很少见。产超广谱β-内酰胺酶/ AmpC酶的大肠杆菌在来自家禽的大肠杆菌和沙门氏菌以及来自人类的大肠杆菌中发生率较低。首次在家禽及其肉中评估的产超广谱β-内酰胺酶/ AmpC酶的大肠杆菌的流行率在各成员国之间存在显著差异。在两个成员国的肉鸡及其肉中检测到14株疑似产碳青霉烯酶的大肠杆菌。在家禽及其肉的大肠杆菌以及来自人类的大肠杆菌中,对黏菌素的耐药性水平较低。在来自人类、肉鸡和鸡胸肉的大肠杆菌中,对环丙沙星和四环素的耐药性为高到极高,而对红霉素的耐药性为低到中等。在来自人类和动物的分离株中,对极为重要的抗菌药物的联合耐药性通常并不常见,但在某些大肠杆菌血清型中观察到非常高到极高的多重耐药水平。来自人类和动物的特定大肠杆菌血清型(特别是肯塔基血清型)除了检测到超广谱β-内酰胺酶外,还对环丙沙星表现出高水平耐药性。