青少年精神病高危人群的睡眠问题与精神病症状减弱。
Sleep problems and attenuated psychotic symptoms in youth at clinical high-risk for psychosis.
机构信息
Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA 30322, USA.
Department of Psychiatry and Behavioral Sciences, Emory School of Medicine, Atlanta, GA, USA; Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA 30322, USA.
出版信息
Psychiatry Res. 2019 Dec;282:112492. doi: 10.1016/j.psychres.2019.112492. Epub 2019 Aug 3.
There has been growing interest on the effect of sleep problems on psychotic and prodromal symptoms. The current study investigated cross-sectional relations between sleep problems and attenuated psychotic symptoms in a large sample of 740 youth at Clinical High Risk (CHR) for psychosis in an attempt to replicate previous findings and assess whether findings from general population samples and psychotic samples extend to this CHR sample. Sleep problems were found to be significantly positively associated with attenuated psychotic symptom severity. Sleep problems were also found to be more closely associated with certain specific prodromal symptoms (e.g., suspiciousness and perceptual abnormalities) than other attenuated psychotic symptoms. Further, we found that depression mediated the cross-sectional association between sleep problems and paranoid symptoms only. This adds to a growing body of evidence suggesting the mediation role of depression is more pronounced for paranoid-type psychotic symptoms as compared to other psychotic symptoms (e.g., hallucinations).
人们对于睡眠问题对精神病和前驱症状的影响越来越感兴趣。本研究在一个大规模的 740 名处于精神病临床高危（CHR）的年轻人样本中，调查了睡眠问题与减弱的精神病症状之间的横断面关系，试图复制先前的发现，并评估一般人群样本和精神病样本的发现是否适用于这个 CHR 样本。研究发现，睡眠问题与减弱的精神病症状严重程度呈显著正相关。此外，研究还发现，睡眠问题与某些特定的前驱症状（如怀疑和知觉异常）比其他减弱的精神病症状更为密切相关。进一步，我们发现抑郁仅在睡眠问题和妄想症状之间的横断面关联中起中介作用。这增加了越来越多的证据表明，与其他精神病症状（如幻觉）相比，抑郁的中介作用在妄想型精神病症状中更为明显。
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