The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 550 N. Broadway Suite 300, Baltimore, MD, 21205, USA.
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline JHOC 3233, Baltimore, MD, 21287, USA.
J Digit Imaging. 2019 Dec;32(6):1071-1080. doi: 10.1007/s10278-019-00255-7.
Extensive research is currently being conducted into dynamic positron emission tomography (PET) acquisitions (including dynamic whole-body imaging) as well as extraction of radiomic features from imaging modalities. We describe a new PET viewing software known as Imager-4D that provides a facile means of viewing and analyzing dynamic PET data and obtaining associated quantitative metrics including radiomic parameters. The Imager-4D was programmed in the Java language utilizing the FX extensions. It is executable on any system for which a Java w/FX compliant virtual machine is available. The software incorporates the ability to view and analyze dynamic data acquired with different types of dynamic protocols. For image display, the program maintains a built-in library of 62 different lookup tables with monochromatic and full-color distributions. The Imager-4D provides multiple display layouts and can display fused images. Multiple methods of volume-of-interest (VOI) selection are available. Dynamic analysis features, such as image summation and full Patlak analysis, are also available. The user interface includes window width and level, blending, and zoom functionality. VOI sizes are adjustable and data from VOIs can either be displayed numerically or graphically within the software or exported. An example case of a 50-year-old woman with metastatic colorectal cancer and thyroiditis is included and demonstrates the steps for a user to obtain standard PET parameters, dynamic data, and radiomic features using selected VOIs. The Imager-4D represents a novel PET viewer that allows the user to view dynamic PET data, to derive dynamic and radiomic parameters from that data, and to combine dynamic data with radiomics ("dynomics"). The Imager-4D is available as a free download. This software has the potential to speed the adoption of advanced analysis of dynamic PET data into routine clinical use.
目前正在进行广泛的研究，包括动态正电子发射断层扫描（PET）采集（包括动态全身成像）以及从成像方式中提取放射组学特征。我们描述了一种新的 PET 查看软件，称为 Imager-4D，它提供了一种简便的方法来查看和分析动态 PET 数据，并获得相关的定量指标，包括放射组学参数。Imager-4D 是使用 Java 语言和 FX 扩展编写的，可以在任何具有 Java w/FX 兼容虚拟机的系统上执行。该软件具有查看和分析使用不同类型动态协议采集的动态数据的能力。对于图像显示，该程序维护一个内置的 62 个不同查找表库，具有单色和全色分布。Imager-4D 提供多种显示布局，并可以显示融合图像。提供了多种感兴趣区（VOI）选择方法。还提供了动态分析功能，例如图像求和和全 Patlak 分析。用户界面包括窗口宽度和级别、混合和缩放功能。VOI 大小可调节，VOI 中的数据可以在软件内部以数字或图形方式显示，也可以导出。包含一个 50 岁女性患有转移性结直肠癌和甲状腺炎的示例案例，演示了用户使用选定的 VOI 获得标准 PET 参数、动态数据和放射组学特征的步骤。Imager-4D 是一种新型的 PET 查看器，允许用户查看动态 PET 数据，从该数据中推导出动态和放射组学参数，并将动态数据与放射组学（“dynomics”）结合。Imager-4D 可免费下载。该软件有可能加速将动态 PET 数据的高级分析纳入常规临床使用。
