Department of Pharmacology Tulane University School of Medicine, New Orleans, Louisiana.
Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F638-F640. doi: 10.1152/ajprenal.00572.2018. Epub 2019 Aug 7.
Sphingolipids were originally believed to play a role only as a backbone of mammalian cell membranes. However, sphingolipid metabolites, especially sphingosine-1-phosphate (S1P), are now recognized as new bioactive signaling molecules that are critically involved in numerous cellular functions of multiple systems including the immune system, central nervous system, and cardiovascular system. S1P research has accelerated in the last decade as new therapeutic drugs have emerged that target the S1P signaling axis to treat diseases of the immune and central nervous systems. There is limited knowledge of the specific effects on cardiovascular disease. This review discusses the current state of knowledge regarding the role of S1P on the regulation of blood pressure, vascular tone, and renal functions.
鞘脂类最初被认为仅在哺乳动物细胞膜中作为骨架发挥作用。然而，鞘脂代谢物，特别是鞘氨醇-1-磷酸（S1P），现在被认为是新的生物活性信号分子，它们在包括免疫系统、中枢神经系统和心血管系统在内的多个系统的多种细胞功能中起着关键作用。随着针对 S1P 信号轴的新型治疗药物的出现，用于治疗免疫系统和中枢神经系统疾病，S1P 的研究在过去十年中加速发展。关于心血管疾病的具体影响，人们的了解有限。本文讨论了目前关于 S1P 在调节血压、血管张力和肾功能方面的作用的知识现状。
