Yan Fengyao, Chen Dan-Qian, Tang Jijun, Zhao Ying-Yong, Guo Yan
Department of Computer Science, University of South Carolina, Columbia, SC 37027, USA.
Faculty of Life Science and Medicine, Northwest University, Xi'an 710127, China.
Metabolites. 2022 Mar 23;12(4):281. doi: 10.3390/metabo12040281.
Blood pressure is one of the most basic health screenings and it has a complex relationship with chronic kidney disease (CKD). Controlling blood pressure for CKD patients is crucial for curbing kidney function decline and reducing the risk of cardiovascular disease. Two independent CKD cohorts, including matched controls (discovery = 824; validation = 552), were recruited. High-throughput metabolomics was conducted with the patients' serum samples using mass spectrometry. After controlling for CKD severity and other clinical hypertension risk factors, we identified ten metabolites that have significant associations with blood pressure. The quantitative importance of these metabolites was verified in a fully connected neural network model. Of the ten metabolites, seven have not previously been associated with blood pressure. The metabolites that had the strongest positive association with blood pressure were aspartylglycosamine ( = 4.58 × 10), fructose-1,6-diphosphate ( = 1.19 × 10) and N-Acetylserine ( = 3.27 × 10). Three metabolites that were negatively associated with blood pressure (phosphocreatine, = 6.39 × 10; dodecanedioic acid, = 0.01; phosphate, = 0.04) have been reported previously to have beneficial effects on hypertension. These results suggest that intake of metabolites as supplements may help to control blood pressure in CKD patients.
血压是最基本的健康筛查项目之一，它与慢性肾脏病（CKD）有着复杂的关系。控制CKD患者的血压对于抑制肾功能衰退和降低心血管疾病风险至关重要。我们招募了两个独立的CKD队列，包括匹配的对照组（发现队列 = 824人；验证队列 = 552人）。使用质谱仪对患者的血清样本进行了高通量代谢组学分析。在控制了CKD严重程度和其他临床高血压风险因素后，我们确定了十种与血压有显著关联的代谢物。这些代谢物的定量重要性在一个全连接神经网络模型中得到了验证。在这十种代谢物中，有七种以前未与血压相关联。与血压呈最强正相关的代谢物是天冬氨酰葡糖胺（= 4.58 × 10）、果糖-1,6-二磷酸（= 1.19 × 10）和N-乙酰丝氨酸（= 3.27 × 10）。三种与血压呈负相关的代谢物（磷酸肌酸，= 6.39 × 10；十二烷二酸，= 0.01；磷酸盐，= 0.04）以前曾被报道对高血压有有益作用。这些结果表明，摄入代谢物作为补充剂可能有助于控制CKD患者的血压。
