Ratsula K, Toivonen J, Allonen H
Department of Medical Chemistry, University of Helsinki, Finland.
Contraception. 1988 Sep;38(3):333-40. doi: 10.1016/0010-7824(88)90105-9.
A levonorgestrel-releasing intracervical device (LNG-ICD) was inserted in 198 women. The subjects registered bleeding and spotting days on special cards, which were analyzed after one year of treatment. Bleeding and spotting days gradually declined from sixteen during the first month to seven during the seventh month, and they remained under that level until the end of the first year. There were more days of spotting than bleeding. Eleven per cent of the subjects experienced at least 90 days non-bleeding interval during the first year of LNG-ICD use. There were no significant changes in blood hemoglobin concentrations during the first four years of LNG-ICD use. The mean serum ferritin concentration increased from 38 micrograms/l at the beginning to 97 micrograms/l at the end of the fourth year.
198名女性植入了左炔诺孕酮宫内节育器（LNG-ICD）。研究对象在特制卡片上记录出血和点滴出血天数，治疗一年后对卡片进行分析。出血和点滴出血天数从第一个月的16天逐渐降至第七个月的7天，直至第一年末均维持在该水平以下。点滴出血天数多于出血天数。11%的研究对象在使用LNG-ICD的第一年至少经历了90天的无出血间隔期。在使用LNG-ICD的前四年，血红蛋白浓度无显著变化。血清铁蛋白平均浓度从开始时的38微克/升升至第四年末的97微克/升。
