Simpamba Micah Mutuna, Chiluba Brian Chanda, Colgrove Yvonne, Wamunyima Mercy, Munalula-Nkandu Esther
School of Health Sciences, University of Zambia, Lusaka, Zambia.
Department of Physical Therapy, Rehabilitation Science and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
PLoS One. 2025 Aug 1;20(8):e0312969. doi: 10.1371/journal.pone.0312969. eCollection 2025.
Cardiovascular diseases (CVDs) have become the most significant contributor to non-HIV/AIDS-related deaths in people living with HIV (PLWH). The increased risk for CVDs in PLWH is attributed to a combination of traditional risk factors, the effects of chronic inflammation, and antiretroviral therapy-related metabolic changes.
The main objective of this scoping review is to systematically map and summarize evidence on the strategies, components, and theories used in health education and physical activity interventions to prevent cardiovascular diseases in PLWH.
Peer-reviewed publications including relevant grey literature published in English will be included. The literature will focus on health education and physical activity interventions for people living with HIV, at risk of CVDs, aged between 18 years to 65 years. The literature publication will range between 2000 and June, 30th 2025, and intervention studies will include diverse research designs and literature sources from a broad array of settings including healthcare and community settings.
Electronic databases to be searched will include PubMed, Scopus, CINAHL, and Embase, as well as grey literature such as Google Scholar, WHO Digital Publications (IRIS), and Proquest Thesis and Dissertation Global. A three-step process of screening consisting of titles/abstracts screening, full article screening, and manual search for references from identified articles will be conducted by two independent reviewers. In case of any discrepancies or disagreements, a third reviewer will be called upon to address the controversy. A data extraction form will be adapted from the Joanne Briggs Institute (JBI) standardized data extraction tool and key findings will be presented in tabular or diagram format followed by a narrative summary. Reporting of the scoping review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist.
The scoping review protocol is registered with Open Science Framework (https://osf.io/4wfkh/).
心血管疾病（CVDs）已成为艾滋病毒感染者（PLWH）中非艾滋病毒/艾滋病相关死亡的最主要原因。艾滋病毒感染者患心血管疾病风险增加归因于传统风险因素、慢性炎症的影响以及抗逆转录病毒疗法相关的代谢变化。
本范围综述的主要目的是系统梳理和总结关于健康教育及体育活动干预中用于预防艾滋病毒感染者心血管疾病的策略、组成部分和理论的证据。
将纳入经同行评审的出版物，包括以英文发表的相关灰色文献。文献将聚焦于年龄在18岁至65岁、有患心血管疾病风险的艾滋病毒感染者的健康教育和体育活动干预。文献发表时间范围为2000年至2025年6月30日，干预研究将包括来自广泛环境（包括医疗保健和社区环境）的多样研究设计和文献来源。
将检索的电子数据库包括PubMed、Scopus、CINAHL和Embase，以及灰色文献，如谷歌学术、世卫组织数字出版物（IRIS）和Proquest全球学位论文。由两名独立评审员进行三步筛选过程，包括标题/摘要筛选、全文筛选以及从已识别文章中手动搜索参考文献。如有任何差异或分歧，将邀请第三位评审员解决争议。数据提取表将改编自乔安妮·布里格斯研究所（JBI）标准化数据提取工具，关键结果将以表格或图表形式呈现，随后进行叙述性总结。范围综述的报告将遵循系统评价和元分析扩展的首选报告项目（PRISMA-ScR）清单。
范围综述方案已在开放科学框架（https://osf.io/4wfkh/）注册。
