Institute of Parasitic Disease Prevention and Control, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, 530028, China.
School of Public Health, Guangxi Medical University, Nanning, 530021, China.
Parasit Vectors. 2019 Aug 9;12(1):398. doi: 10.1186/s13071-019-3653-y.
Echinococcosis has led to considerable social and economic losses in China, particularly in the endemic communities of the eastern Tibetan Plateau. In China, human cases of Echinococcus granulosus (sensu stricto), E. canadensis and E. multilocularis infections have been described, but no E. ortleppi (G5) infections in humans or animals have been reported.
A case of E. ortleppi infection in a human from Guangxi, which is a non-endemic echinococcosis area in China, is described. A 17 × 12 × 20 cm (diameter) cyst was observed in the liver of the patient, and Echinococcus larvae were collected from the cyst. A morphological examination indicated that the larvae were E. ortleppi, and amplification and analysis of the nicotinamide adenine dinucleotide hydrogenase dehydrogenase subunit 1 (nad1) and cytochrome c oxidase subunit 1 (cox1) genes showed that the larvae had 99-100% homology with the corresponding E. ortleppi sequences on GenBank.
To our knowledge, this report describes the first identification of a human E. ortleppi infection in China. Our data broaden the geographical distribution of this rarely reported species of Echinococcus.
包虫病在中国造成了相当大的社会和经济损失，特别是在东部青藏高原的流行社区。在中国，已经描述了人类感染细粒棘球绦虫（狭义）、加拿大棘球绦虫和多房棘球绦虫的病例，但尚未报告在人和动物中感染细粒棘球绦虫（G5）。
描述了一例来自广西的人类感染细粒棘球绦虫（G5）的病例。在患者的肝脏中观察到一个 17×12×20 厘米（直径）的囊肿，从囊肿中收集到棘球蚴幼虫。形态学检查表明幼虫为细粒棘球绦虫，扩增和分析烟酰胺腺嘌呤二核苷酸氢酶亚单位 1（nad1）和细胞色素 c 氧化酶亚单位 1（cox1）基因表明幼虫与 GenBank 上相应的细粒棘球绦虫序列具有 99-100%的同源性。
据我们所知，本报告描述了中国首例人类感染细粒棘球绦虫（G5）的病例。我们的数据扩大了这种罕见报道的棘球属物种的地理分布。
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