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Y 型移植物改良 Fontan 手术:血流逐渐达到平衡。

Y-graft modification to the Fontan procedure: Increasingly balanced flow over time.

机构信息

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Ga.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Ga.

出版信息

J Thorac Cardiovasc Surg. 2020 Feb;159(2):652-661. doi: 10.1016/j.jtcvs.2019.06.063. Epub 2019 Jul 10.

Abstract

OBJECTIVE

The use of Y-grafts for Fontan completion is hypothesized to offer more balanced hepatic flow distribution (HFD) and decreased energy losses. The purpose of this study was to evaluate the hemodynamic performance of Y-grafts over time using serial cardiac magnetic resonance data and to compare their performance with extracardiac Fontan connections.

METHODS

Ten Fontan patients with commercially available Y-graft connections and serial postoperative cardiac magnetic resonance data were included in this study. Patient-specific computational fluid dynamics simulations were used to estimate HFD and energy losses. Y-graft performance was compared with 3 extracardiac conduit Fontan groups (n = 10 for each) whose follow-up times straddle the Y-graft time points.

RESULTS

Y-graft HFD became significantly more balanced over time (deviation from 50% decreased from 18% ± 14% to 8% ± 8%; P = .015). Total cavopulmonary connection resistance did not significantly change. Y-grafts at 3-year follow-up showed more balanced HFD than the extracardiac conduit groups at both the earlier and later follow-up times. Total cavopulmonary connection resistance was not significantly different between any Y-graft or extracardiac conduit group.

CONCLUSIONS

Y-grafts showed significantly more balanced HFD over a 3-year follow-up without an increase in total cavopulmonary connection resistance, and therefore may be a valuable option for Fontan completion. Additional follow-up data at longer follow-up times are still needed to thoroughly characterize the potential advantages of Y-graft use.

摘要

目的

使用 Y 型移植物进行 Fontan 完成术被假设可以提供更平衡的肝血流分布(HFD)和减少能量损失。本研究的目的是使用连续心脏磁共振数据评估 Y 型移植物随时间的血流动力学性能,并将其与体外 Fontan 连接进行比较。

方法

本研究纳入了 10 例具有商业可用 Y 型移植物连接的 Fontan 患者和连续的术后心脏磁共振数据。使用患者特异性计算流体动力学模拟来估计 HFD 和能量损失。将 Y 型移植物的性能与 3 个体外导管 Fontan 组(每组 n = 10)进行比较,这些组的随访时间跨越了 Y 型移植物的时间点。

结果

Y 型移植物的 HFD 随时间变得更加平衡(从 50%的偏差减少了 18%±14%至 8%±8%;P =.015)。总腔静脉肺连接阻力没有显著变化。在 3 年的随访中,Y 型移植物的 HFD 比体外导管组在更早和更晚的随访时间都更加平衡。任何 Y 型移植物或体外导管组之间的总腔静脉肺连接阻力均无显著差异。

结论

Y 型移植物在 3 年的随访中显示出明显更平衡的 HFD,而总腔静脉肺连接阻力没有增加,因此可能是 Fontan 完成术的一种有价值的选择。还需要更长随访时间的额外随访数据来彻底描述 Y 型移植物使用的潜在优势。

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