Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Ga.
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Ga.
J Thorac Cardiovasc Surg. 2020 Feb;159(2):652-661. doi: 10.1016/j.jtcvs.2019.06.063. Epub 2019 Jul 10.
The use of Y-grafts for Fontan completion is hypothesized to offer more balanced hepatic flow distribution (HFD) and decreased energy losses. The purpose of this study was to evaluate the hemodynamic performance of Y-grafts over time using serial cardiac magnetic resonance data and to compare their performance with extracardiac Fontan connections.
Ten Fontan patients with commercially available Y-graft connections and serial postoperative cardiac magnetic resonance data were included in this study. Patient-specific computational fluid dynamics simulations were used to estimate HFD and energy losses. Y-graft performance was compared with 3 extracardiac conduit Fontan groups (n = 10 for each) whose follow-up times straddle the Y-graft time points.
Y-graft HFD became significantly more balanced over time (deviation from 50% decreased from 18% ± 14% to 8% ± 8%; P = .015). Total cavopulmonary connection resistance did not significantly change. Y-grafts at 3-year follow-up showed more balanced HFD than the extracardiac conduit groups at both the earlier and later follow-up times. Total cavopulmonary connection resistance was not significantly different between any Y-graft or extracardiac conduit group.
Y-grafts showed significantly more balanced HFD over a 3-year follow-up without an increase in total cavopulmonary connection resistance, and therefore may be a valuable option for Fontan completion. Additional follow-up data at longer follow-up times are still needed to thoroughly characterize the potential advantages of Y-graft use.
使用 Y 型移植物进行 Fontan 完成术被假设可以提供更平衡的肝血流分布(HFD)和减少能量损失。本研究的目的是使用连续心脏磁共振数据评估 Y 型移植物随时间的血流动力学性能,并将其与体外 Fontan 连接进行比较。
本研究纳入了 10 例具有商业可用 Y 型移植物连接的 Fontan 患者和连续的术后心脏磁共振数据。使用患者特异性计算流体动力学模拟来估计 HFD 和能量损失。将 Y 型移植物的性能与 3 个体外导管 Fontan 组(每组 n = 10)进行比较,这些组的随访时间跨越了 Y 型移植物的时间点。
Y 型移植物的 HFD 随时间变得更加平衡(从 50%的偏差减少了 18%±14%至 8%±8%;P =.015)。总腔静脉肺连接阻力没有显著变化。在 3 年的随访中,Y 型移植物的 HFD 比体外导管组在更早和更晚的随访时间都更加平衡。任何 Y 型移植物或体外导管组之间的总腔静脉肺连接阻力均无显著差异。
Y 型移植物在 3 年的随访中显示出明显更平衡的 HFD,而总腔静脉肺连接阻力没有增加,因此可能是 Fontan 完成术的一种有价值的选择。还需要更长随访时间的额外随访数据来彻底描述 Y 型移植物使用的潜在优势。