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冠心病、高血压与生物质燃料使用:妇女的比较性横断面研究。

Coronary heart disease, hypertension and use of biomass fuel among women: comparative cross-sectional study.

机构信息

Department of Community Health Sciences, Aga Khan University, Karachi, Sindh, Pakistan

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

出版信息

BMJ Open. 2019 Aug 8;9(8):e030881. doi: 10.1136/bmjopen-2019-030881.

Abstract

OBJECTIVES

To explore the associations of hypertension and coronary heart disease (CHD) with use of biomass fuel for cooking.

DESIGN

Comparative cross-sectional study.

SETTING

Rural villages in Sindh, Pakistan.

PARTICIPANTS

Women aged ≥40 years who had used biomass fuel for cooking for at least the last year (n=436), and a comparison group (n=414) who had cooked only with non-biomass fuel during the last year were recruited through door-to-door visits. None of those who were invited to take part declined.

PRIMARY AND SECONDARY OUTCOME MEASURES

Hypertension was determined from blood pressure measurements and use of medication. CHD was assessed by three measures: history of angina (Rose angina questionnaire), previous history of 'heart attack', and definite or probable changes of CHD on ECG. Potentially confounding risk factors were ascertained by questionnaire and anthropometry. Associations of hypertension and CHD with use of biomass and other risk factors were assessed by logistic regression, and summarised by ORs with 95% CIs.

RESULTS

After adjustment for potential confounders, there was no association of hypertension (OR: 1.0, 95% CI 0.8 to 1.4) angina (OR: 1.0, 95% CI 0.8 to 1.4), heart attack (OR: 1.2, 95% 0.7 to 2.2) or ECG changes of CHD (OR: 0.8, 95% CI 0.6 to 1.2) with current use of biomass for cooking. Nor were any associations apparent when analyses were restricted to long-term (≥10 years) users and non-users of biomass fuel.

CONCLUSIONS

A linked air monitoring study indicated substantially higher airborne concentrations of fine particulate matter in kitchens where biomass was used for cooking. It is possible that associations with CHD and hypertension were missed because most of the comparison group had used biomass for cooking at some time in the past, and risk remains elevated for many years after last exposure.

摘要

目的

探讨烹饪用生物质燃料与高血压和冠心病(CHD)的关系。

设计

比较性横断面研究。

地点

巴基斯坦信德省的农村村庄。

参与者

年龄≥40 岁、过去至少使用生物质燃料烹饪 1 年的女性(n=436)和过去 1 年只用非生物质燃料烹饪的对照组(n=414)通过挨家挨户的访问招募。受邀参加的人没有拒绝的。

主要和次要结果测量

通过血压测量和药物使用来确定高血压。CHD 通过三种方法评估:心绞痛史(玫瑰心绞痛问卷)、以前的“心脏病发作”史和心电图上 CHD 的明确或可能变化。通过问卷调查和人体测量来确定潜在的混杂危险因素。通过逻辑回归评估高血压和 CHD 与使用生物质和其他危险因素的关系,并通过 95%CI 的 OR 进行总结。

结果

调整潜在混杂因素后,目前使用生物质烹饪与高血压(OR:1.0,95%CI 0.8 至 1.4)、心绞痛(OR:1.0,95%CI 0.8 至 1.4)、心脏病发作(OR:1.2,95%CI 0.7 至 2.2)或心电图 CHD 变化(OR:0.8,95%CI 0.6 至 1.2)之间无关联。当分析仅限于长期(≥10 年)使用和不使用生物质燃料的用户时,也没有发现任何关联。

结论

一项关联的空气监测研究表明,在使用生物质烹饪的厨房中,空气中细颗粒物的浓度明显更高。与 CHD 和高血压的关联可能被遗漏了,因为对照组中的大多数人过去曾在某个时候使用生物质烹饪过,而且在最后一次暴露后的许多年里,风险仍然很高。

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