Department of Physics, Iran University of Science and Technology, Narmak, Tehran 16844, Iran.
Phys Chem Chem Phys. 2019 Sep 7;21(33):18352-18362. doi: 10.1039/c9cp03126j. Epub 2019 Aug 12.
Graphene coated gold nanoparticles (GGNPs) have attracted great attention in recent years because of their high thermal stability and unique optical properties. In this paper, we study photothermal properties of GGNPs using the Mie and Gans theories combined with the Pennes bioheat equation. The effect of various sizes and different shapes of GGNPs such as nanosphere, nanorod and nanodisc are taken into account. The extinction efficiency and temperature distribution in tumor tissue show that graphene coated gold nanorods, because of the high temperature rise during laser irradiation, are more suitable candidates for photothermal therapy (PTT) applications. Also, we show that the extinction peak of graphene coated gold nanorods can be adjusted in the biological windows by increasing the graphene shell thickness and/or by changing their aspect ratio. Finally, we investigated the effect of the number of graphene layers upon the temperature rise in the tumor and found that the temperature rise increases with increasing number of graphene layers. Our findings introduce a new class of nanoagents which can be used in PTT applications.
近年来，由于具有高热稳定性和独特的光学特性，石墨烯包覆金纳米粒子（GGNPs）引起了广泛关注。本文采用 Mie 和 Gans 理论结合 Pennes 生物传热方程研究了 GGNPs 的光热特性。考虑了不同尺寸和不同形状的 GGNPs，如纳米球、纳米棒和纳米盘。在肿瘤组织中的消光效率和温度分布表明，由于在激光照射过程中产生的高温上升，石墨烯包覆金纳米棒更适合用于光热治疗（PTT）应用。此外，我们还表明，通过增加石墨烯壳层厚度和/或改变其纵横比，可以在生物窗口中调整石墨烯包覆金纳米棒的消光峰。最后，我们研究了石墨烯层数对肿瘤温度升高的影响，发现随着石墨烯层数的增加，温度升高。我们的研究结果介绍了一类可用于 PTT 应用的新型纳米试剂。
