长时间闭塞对人体皮肤微生物菌群、pH值、二氧化碳及经表皮水分流失的影响。

Effect of prolonged occlusion on the microbial flora, pH, carbon dioxide and transepidermal water loss on human skin.

作者信息

Aly R, Shirley C, Cunico B, Maibach H I

出版信息

J Invest Dermatol. 1978 Dec;71(6):378-81. doi: 10.1111/1523-1747.ep12556778.

Abstract

The effects of prolonged occlusion on the normal microbial skin flora, pH, transepidermal water loss (TEWL) and carbon dioxide emission rate (CDER) were studied. The total average counts before occlusion were 1.8 X 10(2)/cm(2) and increased to 4.5 X 10(6) on day 5. The highest counts were noted on day 4(9.8 X 10(7)/cm(2)). The composition changed: controls comprised of 63% coagulase negative staphylococci, 6% micrococci, 17% diphtheroids and 6% bacilli. After 5 days of occlusion, the percent compositon was: 63% coagulase negative staphylococci, 11% micrococci, 4% diphtheroids, 19% lipophilic diphtheroids and less than 0.003% gram negative rods. The pH of the skin before occlusion was 4.38 and increased to 7.05 on day 5. After 5 days of occlusion TEWL increased from 0.56 mg/cm2/hr to 1.87 mg/cm2/hr and CO2 emmission increased from 25 nl/cm2/min to 118 nl/cm2/min.

摘要

研究了长时间封闭对正常皮肤微生物菌群、pH值、经表皮水分流失（TEWL）和二氧化碳排放率（CDER）的影响。封闭前的总平均菌落数为1.8×10²/cm²，在第5天增加到4.5×10⁶/cm²。第4天的菌落数最高（9.8×10⁷/cm²）。其组成发生了变化：对照组中凝固酶阴性葡萄球菌占63%，微球菌占6%，类白喉杆菌占17%，杆菌占6%。封闭5天后，各成分百分比为：凝固酶阴性葡萄球菌63%，微球菌11%，类白喉杆菌4%，亲脂性类白喉杆菌19%，革兰氏阴性杆菌不到0.003%。封闭前皮肤的pH值为4.38，在第5天升至7.05。封闭5天后，TEWL从0.56mg/cm²/小时增加到1.87mg/cm²/小时，二氧化碳排放量从25nl/cm²/分钟增加到118nl/cm²/分钟。