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氯离子通道辅助蛋白mRNA表达在结肠癌中的预后价值

Prognostic value of chloride channel accessory mRNA expression in colon cancer.

作者信息

Pan Xiaohang, Wang Qiaoqi, Xu Chenfei, Yan Ling, Pang Sen, Gan Jialiang

机构信息

Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

Department of Medical Cosmetology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China.

出版信息

Oncol Lett. 2019 Sep;18(3):2967-2976. doi: 10.3892/ol.2019.10615. Epub 2019 Jul 15.

DOI:10.3892/ol.2019.10615
PMID:31404307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6676742/
Abstract

Chloride channel accessory (CLCA) is a gene family that encode Ca activated chloride channels, which make a substantial contribution to various diseases. The aim of the present study was to investigate the prognostic value of CLCA expression in colon cancer. In an attempt to elucidate the value of CLCA mRNA expression in the prognosis of patients with colon cancer, the gene expression data of 438 patients with colon cancer were analyzed. The source of the data was The Cancer Genome Atlas, and it was identified that high expression levels of CLCA1 and CLCA2 were associated with a favorable overall survival (OS) time in patients with colon cancer. As revealed by joint effects analysis, the co-occurrence of high expression levels of CLCA1 and CLCA2 was associated with a favorable OS time in patients with colon cancer. CLCA genes were investigated using gene set enrichment analysis. The results of the bioinformatics analysis demonstrated that high expression levels of CLCA1 and CLCA2 were associated with the prognosis of colon cancer. These findings suggest that CLCA1 and CLCA2 are potential prognostic biomarkers for patients with colon cancer. Furthermore, combining CLCA1 and CLCA2 can enhance the sensitivity of the prediction of the OS time of patients with colon cancer.

摘要

氯离子通道辅助蛋白（CLCA）是一个编码钙激活氯离子通道的基因家族，对多种疾病有重要影响。本研究旨在探讨CLCA表达在结肠癌中的预后价值。为了阐明CLCA mRNA表达在结肠癌患者预后中的价值，分析了438例结肠癌患者的基因表达数据。数据来源为癌症基因组图谱，结果发现CLCA1和CLCA2的高表达水平与结肠癌患者较好的总生存期（OS）相关。联合效应分析显示，CLCA1和CLCA2高表达水平同时出现与结肠癌患者较好的OS时间相关。使用基因集富集分析对CLCA基因进行了研究。生物信息学分析结果表明，CLCA1和CLCA2的高表达水平与结肠癌的预后相关。这些发现提示CLCA1和CLCA2是结肠癌患者潜在的预后生物标志物。此外，联合CLCA1和CLCA2可以提高预测结肠癌患者OS时间的敏感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/dc860175c131/ol-18-03-2967-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/45a8fbc41605/ol-18-03-2967-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/8d94f2f114f5/ol-18-03-2967-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/448fd7d45aad/ol-18-03-2967-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/c66bf4b00405/ol-18-03-2967-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/db08e017eec7/ol-18-03-2967-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/dc860175c131/ol-18-03-2967-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/45a8fbc41605/ol-18-03-2967-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/8d94f2f114f5/ol-18-03-2967-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/448fd7d45aad/ol-18-03-2967-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/c66bf4b00405/ol-18-03-2967-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/db08e017eec7/ol-18-03-2967-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a44/6676742/dc860175c131/ol-18-03-2967-g05.jpg

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CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A.CLCA2 是钙库操纵性钙内流和 TMEM16A 的正向调节剂。
PLoS One. 2018 May 14;13(5):e0196512. doi: 10.1371/journal.pone.0196512. eCollection 2018.
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Cancer statistics, 2018.癌症统计数据，2018 年。
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