Mahat Roshan Kumar, Singh Neelima, Arora Manisha, Rathore Vedika
Department of Biochemistry, Gajra Raja Medical College, Jiwaji University, Gwalior, Madhya Pradesh, 474009, India; Department of Biochemistry, Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh, 251203, India.
University of Kota, Kota, Rajasthan, 324005, India.
Diabetes Metab Syndr. 2019 Jul-Aug;13(4):2803-2811. doi: 10.1016/j.dsx.2019.07.041. Epub 2019 Jul 24.
Prediabetes is a condition which appears prior to the development of diabetes in which blood glucose is abnormally high but do not reach the diagnostic threshold of type 2 diabetes mellitus. It is characterized by a cluster of metabolic abnormalities viz. dysglycemia, dyslipidemia, hypertension, physical inactivity, obesity, insulin resistance, procoagulant state, endothelial dysfunction, oxidative stress and inflammation, placing prediabetic subjects to an increased risk for diabetes and its complications. Recent studies demonstrate that complications of diabetes i.e. microvascular and macrovascular complications may manifest in some prediabetic subjects. This article reviews prediabetes-related risk factors and health issues. In addition, this article also highlights the interventions to prevent the development of diabetes in prediabetic subjects.
糖尿病前期是一种在糖尿病发生之前出现的状况，此时血糖异常升高，但未达到2型糖尿病的诊断阈值。它的特征是一系列代谢异常，即血糖异常、血脂异常、高血压、身体活动不足、肥胖、胰岛素抵抗、促凝状态、内皮功能障碍、氧化应激和炎症，这使得糖尿病前期患者患糖尿病及其并发症的风险增加。最近的研究表明，糖尿病的并发症，即微血管和大血管并发症，可能在一些糖尿病前期患者中出现。本文综述了与糖尿病前期相关的危险因素和健康问题。此外，本文还强调了预防糖尿病前期患者发生糖尿病的干预措施。
