Joffe A M, Hoskins C F, Ghitter-Mannes S C, Mant M J
Department of Medicine, University of Alberta, Edmonton, Canada.
Am J Hematol. 1988 Sep;29(1):56-7. doi: 10.1002/ajh.2830290115.
Lupus anticoagulants are associated with venous and arterial thrombosis and with recurrent spontaneous abortion resulting from placental infarction. Treatment with high-dose prednisone and aspirin has been reported to reduce the otherwise very high frequency of spontaneous abortion in affected women. We report the case of a young woman with an idiopathic lupus anticoagulant who had a history of arterial and venous thrombosis and of previous spontaneous abortion; anticoagulation throughout pregnancy was associated with normal fetal growth and with an absence of placental infarction. We conclude that anticoagulation without concurrent prednisone or aspirin may provide an alternative approach to prevention of habitual abortion in some women with lupus anticoagulants.
狼疮抗凝物与静脉和动脉血栓形成以及胎盘梗死导致的反复自然流产有关。据报道，高剂量泼尼松和阿司匹林治疗可降低患此病女性原本极高的自然流产发生率。我们报告了一名患有特发性狼疮抗凝物的年轻女性病例，她有动脉和静脉血栓形成史以及既往自然流产史；整个孕期进行抗凝治疗，胎儿生长正常且无胎盘梗死。我们得出结论，在一些患有狼疮抗凝物的女性中，不联合使用泼尼松或阿司匹林进行抗凝治疗可能为预防习惯性流产提供一种替代方法。
