Campbell J M, Tate G, Scott J S
Department of Obstetrics & Gynaecology, Huddersfield Royal Infirmary, Leeds, U.K.
Eur J Obstet Gynecol Reprod Biol. 1988 Sep;29(1):27-32. doi: 10.1016/0028-2243(88)90161-x.
A case is described in which a pregnancy, preceded by two mid-trimester fetal losses, was complicated by deep-vein thrombosis due to the presence of circulating lupus anticoagulant. Warfarin was used as anticoagulant therapy concurrently with high-dose prednisolone. It is suggested that warfarin may have advantages over heparin in managing pregnancies in women with circulating lupus anticoagulant. A technique is described which allowed the monitoring of levels of lupus anticoagulant in the circulation while warfarin is being administered.h3.
本文描述了一例病例，该孕妇在孕中期曾有两次胎儿丢失，此次妊娠因循环中狼疮抗凝物的存在而并发深静脉血栓形成。华法林与大剂量泼尼松龙同时用作抗凝治疗。有人认为，在管理患有循环狼疮抗凝物的女性的妊娠时，华法林可能比肝素更具优势。本文描述了一种在使用华法林时监测循环中狼疮抗凝物水平的技术。h3.
