Youn Hyewon, Hong Kee-Jong
Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Cancer Imaging Center, Seoul National University Hospital, Seoul, Korea.
Clin Exp Vaccine Res. 2019 Jul;8(2):89-93. doi: 10.7774/cevr.2019.8.2.89. Epub 2019 Jul 31.
In order to develop a successful vaccine against deadly diseases with a wide range of antigenic diversity, an in-depth knowledge of the molecules and signaling mechanisms between the vaccine candidates and immune cells is required. Therefore, monitoring vaccine components, such as antigen or adjuvants, and immune cell dynamics at the vaccination site or draining lymph nodes can provide important information to understand more about the vaccine response. This review briefly introduces and describes various non-invasive molecular imaging methods for visualizing immune cell dynamics after vaccination.
为了研发出针对具有广泛抗原多样性的致命疾病的成功疫苗，需要深入了解候选疫苗与免疫细胞之间的分子及信号传导机制。因此，监测疫苗成分，如抗原或佐剂，以及接种部位或引流淋巴结处的免疫细胞动态，可以提供重要信息，以更深入地了解疫苗反应。本综述简要介绍并描述了各种用于可视化接种后免疫细胞动态的非侵入性分子成像方法。
