Jin Yanyu, Yang Tao, Li Dongyin, Ding Wentao
Department of General Surgery, Tianjin First Center Hospital, Tianjin, China.
J Int Med Res. 2019 Sep;47(9):4059-4068. doi: 10.1177/0300060519865632. Epub 2019 Aug 13.
This systematic review aimed to explore the potential association between dietary cholesterol intake and esophageal cancer risk.
A literature search was conducted using PubMed, Embase, and Web of Science databases from inception to March 2019 according to specific inclusion and exclusion criteria. Pooled estimates with odds ratio (ORs) and 95% confidence intervals (CIs) were obtained using random effects models.
Nine articles of 12 independent studies were included in the final meta-analysis. Pooled analysis suggested that dietary cholesterol intake may increase the risk of esophageal cancer (summarized OR = 1.424, 95% CI = 1.191–1.704). Consistent results were found in American (summarized OR = 1.410, 95% CI = 1.130–1.758) and European populations (summarized OR = 1.556, 95% CI = 1.021–2.373). Subgroup analysis by disease type showed that dietary cholesterol intake had a significant association with the development of esophageal adenocarcinoma and esophageal squamous cell carcinoma.
Our findings indicated that dietary cholesterol intake could significantly increase the risk of developing esophageal cancer in both European and American populations. Further high-quality studies are necessary to confirm the effects of cholesterol intake.
本系统评价旨在探讨膳食胆固醇摄入量与食管癌风险之间的潜在关联。
根据特定的纳入和排除标准，使用PubMed、Embase和Web of Science数据库从建库至2019年3月进行文献检索。采用随机效应模型获得合并估计值及比值比（OR）和95%置信区间（CI）。
最终的荟萃分析纳入了12项独立研究中的9篇文章。合并分析表明，膳食胆固醇摄入可能增加食管癌风险（汇总OR = 1.424，95% CI = 1.191 - 1.704）。在美国人群（汇总OR = 1.410，95% CI = 1.130 - 1.758）和欧洲人群（汇总OR = 1.556，95% CI = 1.021 - 2.373）中发现了一致的结果。按疾病类型进行的亚组分析表明，膳食胆固醇摄入与食管腺癌和食管鳞状细胞癌的发生有显著关联。
我们的研究结果表明，膳食胆固醇摄入可显著增加欧美人群患食管癌的风险。需要进一步的高质量研究来证实胆固醇摄入的影响。
