State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3499-3506. doi: 10.1167/iovs.19-27164.
We investigate the impact of parental myopia on spherical equivalent (SE) progression and axial length (AL) elongation.
Children and their parents were invited for annual examinations from 2006 (baseline). Cycloplegic autorefraction and AL were measured at each visit. Parental refractive status was determined using refraction data from their baseline visit. Children were classified into five groups: no myopic parents (non-non), only one moderately myopic parent (non-moderate), only one highly myopic parent (non-high), two moderately myopic parents (moderate-moderate), and one moderately myopic or more severe and one highly myopic parent (moderate-high/high-high). The relationship between progression of SE and AL with parental refractive status was estimated by linear mixed-effects models. Data from 2006 to 2017 were analyzed in the current study.
A total of 1831 children were enrolled (mean age, 11 ± 2.7 years; mean standard error, -0.49 ± 2.16 diopters [D] at baseline. Myopia progressed faster for children with parental myopia (non-non group as reference, all P < 0.05), while AL elongation mirrored the change in SE (all P < 0.001 except for non-mod group P = 0.12). As for the age-specific change in SE and AL, children in the mod-high/high-high group presented with the fastest progression. Children with highly myopic parents were at higher risks of being highly myopic during adulthood (odds ratio = 13.98 and 25.71 for non-high and mod-high/high-high groups; both P < 0.001).
SE progresses and AL elongates at a faster rate at an earlier age in children with parental myopia. Children with highly-myopic parents have higher risks of being highly myopic during adulthood.
我们研究了父母近视对球镜等效（SE）进展和眼轴（AL）伸长的影响。
我们邀请儿童及其父母从 2006 年（基线）开始每年进行一次检查。每次就诊时都进行睫状肌麻痹自动验光和 AL 测量。使用他们基线就诊时的验光数据确定父母的屈光状态。根据父母的近视情况，将儿童分为五组：无近视父母（非非）、只有一位中度近视父母（非中度）、只有一位高度近视父母（非高度）、两位中度近视父母（中度中度）和一位中度或更高度近视和一位高度近视父母（中度高度/高度高度）。通过线性混合效应模型估计 SE 和 AL 的进展与父母屈光状态之间的关系。本研究分析了 2006 年至 2017 年的数据。
共纳入 1831 名儿童（平均年龄 11 ± 2.7 岁；平均标准误差为-0.49 ± 2.16 屈光度[D]，基线时）。与非近视父母组（参考组）相比，有父母近视的儿童近视进展更快（所有 P < 0.05），而 AL 伸长与 SE 变化一致（除非中度组 P = 0.12 外，所有 P < 0.001）。至于 SE 和 AL 的年龄特异性变化，高中度/高度高度组的儿童进展最快。高度近视父母的儿童成年后患高度近视的风险更高（非高度和高中度/高度高度组的比值比分别为 13.98 和 25.71；均 P < 0.001）。
父母近视的儿童 SE 进展更快，AL 伸长也更早。高度近视父母的儿童成年后患高度近视的风险更高。
