Swerdlow A J, English J S, MacKie R M, O'Doherty C J, Hunter J A, Clark J, Hole D J
Department of Community Medicine, University of Glasgow.
BMJ. 1988 Sep 10;297(6649):647-50. doi: 10.1136/bmj.297.6649.647.
Exposure to solar radiation is increasingly being associated with a risk of cutaneous melanoma, and some risk has also been attributed to exposure to fluorescent lights. The risk of cutaneous melanoma associated with exposure to some sources of artificial ultraviolet radiation was examined in a case-control study in a Scottish population with fairly low exposure to natural ultraviolet radiation. The risk was not significantly or consistently raised for exposure to fluorescent lights at home or at work. The use of ultraviolet lamps and sunbeds, however, was associated with a significantly increased risk (relative risk = 2.9; 95% confidence interval 1.3 to 6.4), and the risk was significantly related to duration of use. The risk was particularly raised among people who have first used [corrected] ultraviolet beds or lamps more than [corrected] five years before presentation (relative risk = 9.1; 95% confidence intervals 2.0-40.6), in whom it was significantly related to cumulative hours of exposure. The risks associated with exposure to ultraviolet lamps and sunbeds remained significant after adjustment for other risk factors for melanoma.
暴露于太阳辐射与皮肤黑素瘤风险的关联日益增加，而且一些风险也归因于暴露于荧光灯下。在一个自然紫外线辐射暴露水平相当低的苏格兰人群中开展的病例对照研究，对与暴露于某些人工紫外线辐射源相关的皮肤黑素瘤风险进行了调查。在家中或工作场所暴露于荧光灯下，风险并未显著或持续升高。然而，使用紫外线灯和日光浴床与风险显著增加相关（相对风险 = 2.9；95%置信区间1.3至6.4），且该风险与使用时长显著相关。在就诊前五年多首次使用紫外线床或灯的人群中，风险尤其升高（相对风险 = 9.1；95%置信区间2.0 - 40.6），在这些人群中，风险与累计暴露时长显著相关。在对黑素瘤的其他风险因素进行调整后，与暴露于紫外线灯和日光浴床相关的风险仍然显著。
