DRAMP 2.0，一个更新的抗菌肽数据库。
DRAMP 2.0, an updated data repository of antimicrobial peptides.
机构信息
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211100, P.R. China.
State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, P.R. China.
出版信息
Sci Data. 2019 Aug 13;6(1):148. doi: 10.1038/s41597-019-0154-y.
Data Repository of Antimicrobial Peptides (DRAMP, http://dramp.cpu-bioinfor.org/ ) is an open-access comprehensive database containing general, patent and clinical antimicrobial peptides (AMPs). Currently DRAMP has been updated to version 2.0, it contains a total of 19,899 entries (newly added 2,550 entries), including 5,084 general entries, 14,739 patent entries, and 76 clinical entries. The update covers new entries, structures, annotations, classifications and downloads. Compared with APD and CAMP, DRAMP contains 14,040 (70.56% in DRAMP) non-overlapping sequences. In order to facilitate users to trace original references, PubMed_ID of references have been contained in activity information. The data of DRAMP can be downloaded by dataset and activity, and the website source code is also available on dedicatedly designed download webpage. Although thousands of AMPs have been reported, only a few parts have entered clinical stage. In the paper, we described several AMPs in clinical trials, including their properties, indications and clinicaltrials.gov identifiers. Finally, we provide the applications of DRAMP in the development of AMPs.
抗菌肽数据库（DRAMP，http://dramp.cpu-bioinfor.org/ ）是一个开放获取的综合数据库，包含一般、专利和临床抗菌肽（AMPs）。目前，DRAMP 已更新到 2.0 版本，它包含总共 19899 条记录（新增加 2550 条记录），包括 5084 条一般记录、14739 条专利记录和 76 条临床记录。更新涵盖了新的条目、结构、注释、分类和下载。与 APD 和 CAMP 相比，DRAMP 包含 14040 条（DRAMP 中的 70.56%）非重叠序列。为了方便用户追踪原始参考文献，参考文献的 PubMed_ID 已包含在活性信息中。DRAMP 的数据可以按数据集和活性进行下载，网站源代码也可以在专门设计的下载网页上获得。尽管已经报道了数千种 AMPs，但只有少数部分进入了临床阶段。在本文中，我们描述了几种正在临床试验中的 AMPs，包括它们的性质、适应症和临床实验.gov 标识符。最后，我们提供了 DRAMP 在 AMPs 开发中的应用。
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