Xue Lijun, Chen Yang Yizhi, Yan Zhiyun, Lu Wei, Wan Dong, Zhu Huifeng
College of Pharmaceutical Sciences and Traditional Chinese Medicine, Southwest University, Chongqing 400715, People's Republic of China.
College of Pharmaceutical Engineering, Chongqing Chemical Industry Vocational College, Chongqing, 400020, People's Republic of China.
Infect Drug Resist. 2019 Jul 17;12:2151-2160. doi: 10.2147/IDR.S193649. eCollection 2019.
Staphylococcus aureus is an important and common Gram-positive bacteria which causes clinical infections and food-poisoning cases. Therapeutic schedules for treatment of infections are facing a challenge because of the emergence of multidrug resistance strains. It is urgent to find new antiinfective drugs to control S. aureus infection. S. aureus strains are capable of producing the golden carotenoid pigment: staphyloxanthin, which acts as an important virulence factor and a potential target for antivirulence drug design. This review is aimed at presenting an updated overview of this golden carotenoid pigment of S. aureus from the biosynthesis of staphyloxanthin, its function, and the genes involved in pigment production to staphyloxanthin: a novel target for antivirulence therapy.
金黄色葡萄球菌是一种重要且常见的革兰氏阳性细菌，可引发临床感染和食物中毒病例。由于多重耐药菌株的出现，治疗感染的治疗方案面临挑战。迫切需要寻找新的抗感染药物来控制金黄色葡萄球菌感染。金黄色葡萄球菌菌株能够产生金色类胡萝卜素色素：葡萄球菌黄素，它是一种重要的毒力因子，也是抗毒力药物设计的潜在靶点。本综述旨在从葡萄球菌黄素的生物合成、其功能以及参与色素产生的基因等方面，对金黄色葡萄球菌的这种金色类胡萝卜素色素进行最新概述，以探讨葡萄球菌黄素：一种抗毒力治疗的新靶点。
