Quadram Institute Bioscience, Colney Lane, Norwich, NR4 7UQ, UK.
Medical School, University of East Anglia, Norwich, UK.
Mol Nutr Food Res. 2019 Oct;63(20):e1900461. doi: 10.1002/mnfr.201900461. Epub 2019 Sep 11.
Observational studies have associated consumption of cruciferous vegetables with reduced risk of prostate cancer. This effect has been associated with the degradation products of glucosinolates-thioglycosides that accumulate within crucifers. The possible role of S-methyl cysteine sulfoxide, a metabolite that also accumulates in cruciferous vegetables, and its derivatives, in cancer prevention is relatively unexplored compared to glucosinolate derivatives. The hypothesis that consuming a broccoli soup results in the accumulation of sulfate (a SMCSO derivative) and other broccoli-derived metabolites in prostate tissue is tested.
Eighteen men scheduled for transperineal prostate biopsy were recruited into a 4-week parallel single blinded diet supplementation study (NCT02821728). Nine men supplemented their diet with three 300 mL portions of a broccoli soup each week for four weeks prior to surgery. Analyses of prostate biopsy tissues reveal no detectable levels of glucosinolates and derivatives. In contrast, SMCSO is detected in prostate tissues of the participants, with significantly higher levels in tissue of men in the supplementation arm. SMCSO was also found in blood and urine samples from a previous intervention study with the identical broccoli soup.
The consequences of SMCSO accumulation in prostate tissues and its potential role in prevention of prostate cancer remains to be investigated.
观察性研究表明，食用十字花科蔬菜与降低前列腺癌风险有关。这种效应与硫代葡萄糖苷——在十字花科蔬菜中积累的糖苷——的降解产物有关。与硫代葡萄糖苷衍生物相比，相对而言，甲硫氨酸亚砜（一种也在十字花科蔬菜中积累的代谢物）及其衍生物在癌症预防中的可能作用尚未得到充分探索。本研究旨在检验以下假设：食用西兰花汤会导致前列腺组织中硫酸盐（SMCSO 衍生物）和其他西兰花衍生代谢物的积累。
18 名计划接受经会阴前列腺活检的男性被招募到一项为期 4 周的平行单盲饮食补充研究中（NCT02821728）。9 名男性在手术前的四周内每周补充三次 300 毫升的西兰花汤。对前列腺活检组织的分析显示，没有检测到硫代葡萄糖苷及其衍生物。相比之下，SMCSO 存在于参与者的前列腺组织中，补充组男性组织中的水平明显更高。在之前一项使用相同西兰花汤的干预研究中，也在血液和尿液样本中发现了 SMCSO。
SMCSO 在前列腺组织中的积累及其在预防前列腺癌中的潜在作用仍有待进一步研究。
