Smith S M, Eng R H
Laboratory Service, VA Medical Center, East Orange, NJ 07019.
Diagn Microbiol Infect Dis. 1988 Apr;9(4):239-43. doi: 10.1016/0732-8893(88)90115-0.
Streptococcus faecalis is known to be resistant to killing by many of the commonly used antimicrobial agents. Ciprofloxacin, a member of the quinolone class of compounds, was studied for its ability to inhibit and to kill S. faecalis. The rate of killing by ciprofloxacin was slow and was comparable to that of ampicillin or vancomycin. The antimicrobial effect of combining ciprofloxacin with ampicillin or with vancomycin was also studied using checkerboard double-dilution and killing kinetics. There was no synergy or antagonism between ciprofloxacin and either cell wall active agent. Unlike the aminoglycosides, the addition of ciprofloxacin did not produce additional killing over that of ampicillin or of vancomycin alone.
已知粪肠球菌对许多常用抗菌剂的杀灭作用具有抗性。环丙沙星是喹诺酮类化合物的一种，对其抑制和杀灭粪肠球菌的能力进行了研究。环丙沙星的杀菌速度较慢，与氨苄西林或万古霉素相当。还使用棋盘法双倍稀释法和杀菌动力学研究了环丙沙星与氨苄西林或万古霉素联合使用的抗菌效果。环丙沙星与任何一种细胞壁活性剂之间均无协同或拮抗作用。与氨基糖苷类不同，添加环丙沙星不会比单独使用氨苄西林或万古霉素产生额外的杀菌效果。
