H-2 连锁对体外γ干扰素产生的控制，该产生是对卡介苗牛分枝杆菌32千道尔顿抗原（P32）的反应。
H-2-linked control of in vitro gamma interferon production in response to a 32-kilodalton antigen (P32) of Mycobacterium bovis bacillus Calmette-Guérin.
作者信息
Huygen K, Palfliet K, Jurion F, Hilgers J, ten Berg R, Van Vooren J P, De Bruyn J
机构信息
Pasteur Institute of Brabant, Brussels, Belgium.
出版信息
Infect Immun. 1988 Dec;56(12):3196-200. doi: 10.1128/iai.56.12.3196-3200.1988.
Abstract
A 32-kilodalton protein antigen (P32) was previously purified to homogeneity from culture filtrate of Mycobacterium bovis BCG (J. De Bruyn, K. Huygen, R. Bosmans, M. Fauville, R. Lippens, J. P. Van Vooren, P. Falmagne, H. G. Wiker, M. Harboe, and M. Turneer, Microb. Pathog. 2:351-366, 1987). Spleen cells from BCG-sensitized mice produce significant amounts of gamma interferon (IFN-gamma) in response to this P32 protein. The amount of secreted IFN-gamma is influenced by mouse genotype, with C57BL/6 (H-2b), C57BL/10 (H-2b), and 129/Sv (H-2b) mice producing about four times more than BALB/c (H-2d), CBF1 (H-2d/b), and DBA/2 (H-2d) mice do. Analysis of seven recombinant inbred strains derived from the BALB/c x C57BL/6 cross and of congenic mice differing in major histocompatibility complex-coding chromosome 17 fragments indicates a probable H-2-linked control of this IFN-gamma induction, with H-2b cells producing high titers and H-2d cells producing low titers in response to the P32 antigen.
摘要
一种32千道尔顿的蛋白质抗原（P32）先前已从卡介苗的培养滤液中纯化至同质（J.德布鲁因、K.惠根、R.博斯曼斯、M.福维尔、R.利彭斯、J.P.范沃伦、P.法尔马涅、H.G.维克、M.哈博和M.图尔内尔，《微生物病原体》2:351 - 366，1987年）。来自卡介苗致敏小鼠的脾细胞对这种P32蛋白产生大量的γ干扰素（IFN - γ）。分泌的IFN - γ量受小鼠基因型影响，C57BL/6（H - 2b）、C57BL/10（H - 2b）和129/Sv（H - 2b）小鼠产生的量约为BALB/c（H - 2d）、CBF1（H - 2d/b）和DBA/2（H - 2d）小鼠的四倍。对源自BALB/c×C57BL/6杂交的七个重组近交系以及在主要组织相容性复合体编码的第17号染色体片段上存在差异的同源小鼠进行分析，表明这种IFN - γ诱导可能受H - 2连锁控制，H - 2b细胞对P32抗原产生高滴度反应，而H - 2d细胞产生低滴度反应。
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H-2-linked control of in vitro gamma interferon production in response to a 32-kilodalton antigen (P32) of Mycobacterium bovis bacillus Calmette-Guérin.H-2 连锁对体外γ干扰素产生的控制，该产生是对卡介苗牛分枝杆菌32千道尔顿抗原（P32）的反应。
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