Yamashita T
Research Laboratories, Nippon Kayaku Co., Ltd., Tokyo.
Jpn J Cancer Res. 1988 Aug;79(8):945-51. doi: 10.1111/j.1349-7006.1988.tb00059.x.
The biological properties of human gastric cancer cell line G/F implanted into either the subcutis or the stomach wall of nude mice were compared. The G/F tumor in the stomach wall showed a slower growth rate than that in the subcutis. The level of carcinoembryonic antigen in serum was greater when the tumor was in the stomach wall than when it was in the subcutis. The tumor in the stomach wall invaded the surrounding tissues and metastasized to the regional lymph nodes and distant organs such as the lung and the liver in 27 of the 43 mice (68%). In contrast, the tumor in the subcutis was highly encapsulated and metastasis to other organs was not observed. These findings indicate that the stomach wall might provide a suitable microenvironment for G/F gastric cancer to exert its intrinsic properties. Therefore, implantation of human gastric cancer into the stomach wall of nude mice may provide a useful model to study the intrinsic characteristics of human cancer as well as the effectiveness of experimental chemotherapy.
比较了人胃癌细胞系G/F接种于裸鼠皮下或胃壁后的生物学特性。胃壁中的G/F肿瘤生长速度比皮下的慢。肿瘤位于胃壁时血清癌胚抗原水平高于位于皮下时。胃壁中的肿瘤侵袭周围组织，并转移至区域淋巴结以及远处器官，如肺和肝脏，43只小鼠中有27只出现转移（68%）。相比之下，皮下肿瘤包膜完整，未观察到向其他器官转移。这些发现表明胃壁可能为G/F胃癌发挥其固有特性提供适宜的微环境。因此，将人胃癌接种于裸鼠胃壁可能为研究人类癌症的固有特征以及实验性化疗的效果提供有用的模型。
