Dixon J B, Allan D, West C R
Res Vet Sci. 1979 Jan;26(1):59-65.
The purpose of these investigations was to assemble and compare data which might illustrate a functional relationship between phytohaemagglutinin-induced transformation of equine lymphocytes in vitro and the haematological profiles of the lymphocyte donors. Statistically significant correlation between transformation and a haematological parameter was taken as evidence that both may be part of a common regulatory system. There was no evidence that transformation in vitro was affected by artefactual variation in the cellular composition of the cultures. Transformational behaviour of lymphocytes in autologous plasma showed significant correlation with donors' total leucocyte, neutrophil and T cell count. Different batches of donor plasma varied in ability to support the transformation and this ability was found to correlate significantly with the total leucocyte, eosinophil, lymphocyte and T cell count of the original blood. It is concluded that previously reported variation in transformation ratios of normal equine lymphocytes is attributable to regulatory mechanisms affecting circulating blood as a whole and that helminth parasitism may be among the primary causal agents which modify the mechanism.
这些研究的目的是收集并比较相关数据，以阐明体外植物血凝素诱导马淋巴细胞转化与淋巴细胞供体血液学特征之间的功能关系。转化与血液学参数之间具有统计学意义的相关性被视为两者可能是共同调节系统一部分的证据。没有证据表明体外转化受培养物细胞组成的人为变化影响。淋巴细胞在自体血浆中的转化行为与供体的总白细胞、中性粒细胞和T细胞计数显著相关。不同批次的供体血浆在支持转化的能力上存在差异，并且发现这种能力与原始血液中的总白细胞、嗜酸性粒细胞、淋巴细胞和T细胞计数显著相关。得出的结论是，先前报道的正常马淋巴细胞转化比率的变化归因于影响整个循环血液的调节机制，并且蠕虫寄生可能是改变该机制的主要致病因素之一。
