面包衍生的生物活性多孔支架：骨组织工程的创新和可持续方法。
Bread-Derived Bioactive Porous Scaffolds: An Innovative and Sustainable Approach to Bone Tissue Engineering.
机构信息
Institute of Materials Physics and Engineering, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso duca degli Abruzzi 24, 10129 Torino, Italy.
Department of Mechanical and Aerospace Engineering (DIMEAS), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
出版信息
Molecules. 2019 Aug 14;24(16):2954. doi: 10.3390/molecules24162954.
In recent years, bioactive glasses gained increasing scientific interest in bone tissue engineering due to their capability to chemically bond with the host tissue and to induce osteogenesis. As a result, several efforts have been addressed to use bioactive glasses in the production of three-dimensional (3D) porous scaffolds for bone regeneration. In this work, we creatively combine typical concepts of porous glass processing with those of waste management and propose, for the first time, the use of bread as a new sacrificial template for the fabrication of bioactive scaffolds. Preliminary SEM investigations performed on stale bread from industrial wastes revealed a suitable morphology characterized by an open-cell 3D architecture, which is potentially able to allow tissue ingrowth and vascularization. Morphological features, mechanical performances and in vitro bioactivity tests were performed in order to evaluate the properties of these new "sustainable" scaffolds for bone replacement and regeneration. Scaffolds with total porosity ranging from 70 to 85 vol% and mechanical strength comparable to cancellous bone were obtained. Globular hydroxyapatite was observed to form on the surface of the scaffolds after just 48-h immersion in simulated body fluid. The results show great promise and suggest the possibility to use bread as an innovative and inexpensive template for the development of highly-sustainable bone tissue engineering approaches.
近年来，生物活性玻璃因其能够与宿主组织发生化学结合并诱导成骨作用，在骨组织工程领域引起了越来越多的科学关注。因此，人们已经做出了一些努力，将生物活性玻璃用于生产用于骨再生的三维（3D）多孔支架。在这项工作中，我们创造性地将典型的多孔玻璃加工概念与废物管理概念相结合，并首次提出使用面包作为生物活性支架制造的新牺牲模板。对来自工业废物的陈旧面包进行的初步 SEM 研究揭示了一种合适的形态特征，其具有开放细胞 3D 结构，这可能能够允许组织向内生长和血管化。为了评估这些用于骨替代和再生的新型“可持续”支架的性能，对其进行了形态特征、机械性能和体外生物活性测试。获得了总孔隙率为 70%至 85%、机械强度可与松质骨相媲美的支架。在模拟体液中浸泡仅 48 小时后，观察到球形羟基磷灰石在支架表面形成。结果表明具有很大的应用前景，并表明可以使用面包作为开发高度可持续骨组织工程方法的创新且廉价的模板。
Zotero 插件