• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
New approaches for detecting cancer with circulating cell-free DNA.利用循环游离DNA检测癌症的新方法。
BMC Med. 2019 Aug 16;17(1):159. doi: 10.1186/s12916-019-1400-z.
2
Cell-free DNA in maternal blood and artificial intelligence: accurate prenatal detection of fetal congenital heart defects.母体外周血游离 DNA 和人工智能：准确产前检测胎儿先天性心脏缺陷。
Am J Obstet Gynecol. 2023 Jan;228(1):76.e1-76.e10. doi: 10.1016/j.ajog.2022.07.062. Epub 2022 Aug 7.
3
Recent advances in blood-based and artificial intelligence-enhanced approaches for gastrointestinal cancer diagnosis.基于血液的和人工智能增强的胃肠道癌症诊断方法的最新进展。
World J Gastroenterol. 2021 Sep 14;27(34):5666-5681. doi: 10.3748/wjg.v27.i34.5666.
4
The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening.20世纪关于循环DNA作为癌症筛查生物标志物的发现所做的贡献。
An Acad Bras Cienc. 2020 Nov 16;92(4):e20200919. doi: 10.1590/0001-3765202020200919. eCollection 2020.
5
Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients.循环肿瘤 DNA 中的体细胞拷贝数改变和片段分析用于结直肠癌患者的癌症筛查和治疗监测。
J Hematol Oncol. 2022 Sep 2;15(1):125. doi: 10.1186/s13045-022-01342-z.
6
Circulating cell-free DNA from plasma undergoes less fragmentation during bisulfite treatment than genomic DNA due to low molecular weight.由于分子量较低，来自血浆的循环无细胞 DNA 在亚硫酸氢盐处理过程中的碎片化程度低于基因组 DNA。
PLoS One. 2019 Oct 25;14(10):e0224338. doi: 10.1371/journal.pone.0224338. eCollection 2019.
7
Inferring gene expression from cell-free DNA fragmentation profiles.从游离 DNA 片段化特征推断基因表达。
Nat Biotechnol. 2022 Apr;40(4):585-597. doi: 10.1038/s41587-022-01222-4. Epub 2022 Mar 31.
8
Epigenetic Biomarkers in Cell-Free DNA and Applications in Liquid Biopsy.无细胞游离 DNA 中的表观遗传生物标志物及其在液体活检中的应用。
Genes (Basel). 2019 Jan 9;10(1):32. doi: 10.3390/genes10010032.
9
Liquid biopsy: state of reproductive medicine and beyond.液体活检：生殖医学领域的现状及展望。
Hum Reprod. 2021 Oct 18;36(11):2824-2839. doi: 10.1093/humrep/deab206.
10
Integrity and Quantity of Total Cell-Free DNA in the Diagnosis of Thyroid Cancer: Correlation with Cytological Classification.游离DNA总量的完整性和数量在甲状腺癌诊断中的应用：与细胞学分类的相关性
Int J Mol Sci. 2017 Jun 24;18(7):1350. doi: 10.3390/ijms18071350.

引用本文的文献

1
Graphene-based wearable biosensors for point-of-care diagnostics: From surface functionalization to biomarker detection.用于即时诊断的基于石墨烯的可穿戴生物传感器：从表面功能化到生物标志物检测。
Mater Today Bio. 2025 Mar 14;32:101667. doi: 10.1016/j.mtbio.2025.101667. eCollection 2025 Jun.
2
Utilizing Two Electrokinetic Techniques on a Single Device for Detection of Extracellular Vesicle-Associated Protease Activity.在单个设备上利用两种电动技术检测细胞外囊泡相关蛋白酶活性。
Small. 2025 Jun;21(24):e2404457. doi: 10.1002/smll.202404457. Epub 2025 Mar 26.
3
Application progress of artificial intelligence in tumor diagnosis and treatment.人工智能在肿瘤诊疗中的应用进展
Front Artif Intell. 2025 Jan 7;7:1487207. doi: 10.3389/frai.2024.1487207. eCollection 2024.
4
What does cancer screening have to do with tomato growing?癌症筛查与种植番茄有什么关系？
Clin Chem Lab Med. 2025 Jan 20;63(7):1286-1291. doi: 10.1515/cclm-2024-1408. Print 2025 Jun 26.
5
Multiplex digital profiling of DNA methylation heterogeneity for sensitive and cost-effective cancer detection in low-volume liquid biopsies.多重数字分析 DNA 甲基化异质性，用于在低容量液体活检中进行敏感且具有成本效益的癌症检测。
Sci Adv. 2024 Nov 22;10(47):eadp1704. doi: 10.1126/sciadv.adp1704.
6
Evolutionary Characteristics and Immunologic Divergence of Lung and Brain Metastasis Lesions in NSCLC.非小细胞肺癌肺及脑转移瘤的进化特征和免疫差异。
Mol Cancer Res. 2023 Apr 1;21(4):374-385. doi: 10.1158/1541-7786.MCR-22-0474.
7
The current applications of cell-free fetal DNA in prenatal diagnosis of single-gene diseases: A review.游离胎儿DNA在单基因疾病产前诊断中的当前应用：综述
Int J Reprod Biomed. 2022 Sep 6;20(8):613-626. doi: 10.18502/ijrm.v20i8.11751. eCollection 2022 Aug.
8
Modified Taq DNA Polymerase for Allele-Specific Ultra-Sensitive Detection of Genetic Variants.经改良的 Taq DNA 聚合酶，用于等位基因特异性超灵敏检测遗传变异。
J Mol Diagn. 2022 Nov;24(11):1128-1142. doi: 10.1016/j.jmoldx.2022.08.002. Epub 2022 Sep 2.
9
Next-Generation Sequencing on Circulating Tumor DNA in Advanced Solid Cancer: Swiss Army Knife for the Molecular Tumor Board? A Review of the Literature Focused on FDA Approved Test.循环肿瘤 DNA 的下一代测序在晚期实体瘤中的应用：分子肿瘤委员会的瑞士军刀？聚焦 FDA 批准检测的文献综述。
Cells. 2022 Jun 11;11(12):1901. doi: 10.3390/cells11121901.
10
Fragment Size-Based Enrichment of Viral Sequences in Plasma Cell-Free DNA.基于片段大小的血浆游离 DNA 中病毒序列富集。
J Mol Diagn. 2022 May;24(5):476-484. doi: 10.1016/j.jmoldx.2022.01.007. Epub 2022 Feb 22.

本文引用的文献

1
Circulating Tumor DNA for Early Cancer Detection.用于早期癌症检测的循环肿瘤DNA
J Appl Lab Med. 2018 Sep 1;3(2):300-313. doi: 10.1373/jalm.2018.026393.
2
Mutated clones are the new normal.突变克隆是新的常态。
Science. 2019 Jun 7;364(6444):938-939. doi: 10.1126/science.aax5525.
3
Genome-wide cell-free DNA fragmentation in patients with cancer.癌症患者的全基因组游离 DNA 片段化。
Nature. 2019 Jun;570(7761):385-389. doi: 10.1038/s41586-019-1272-6. Epub 2019 May 29.
4
Utility of circulating tumor DNA in cancer diagnostics with emphasis on early detection.循环肿瘤 DNA 在癌症诊断中的应用，重点是早期检测。
BMC Med. 2018 Oct 2;16(1):166. doi: 10.1186/s12916-018-1157-9.
5
Detection and localization of surgically resectable cancers with a multi-analyte blood test.通过多分析物血液检测对外科可切除癌症进行检测和定位。
Science. 2018 Feb 23;359(6378):926-930. doi: 10.1126/science.aar3247. Epub 2018 Jan 18.
6
Can circulating tumor DNA be used for direct and early stage cancer detection?循环肿瘤DNA可用于癌症的直接早期检测吗？
F1000Res. 2017 Dec 13;6:2129. doi: 10.12688/f1000research.13440.1. eCollection 2017.
7
Direct detection of early-stage cancers using circulating tumor DNA.利用循环肿瘤DNA直接检测早期癌症。
Sci Transl Med. 2017 Aug 16;9(403). doi: 10.1126/scitranslmed.aan2415.
8
Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.在前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验标本中卵巢癌生物标志物的性能。
Cancer Prev Res (Phila). 2011 Mar;4(3):365-74. doi: 10.1158/1940-6207.CAPR-10-0195.

New approaches for detecting cancer with circulating cell-free DNA.

作者信息

Fiala Clare, Diamandis Eleftherios P

机构信息

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

出版信息

BMC Med. 2019 Aug 16;17(1):159. doi: 10.1186/s12916-019-1400-z.

DOI:10.1186/s12916-019-1400-z
PMID:31416458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6696683/
Abstract
摘要