Department of Clinical Genetics, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Hum Reprod. 2021 Oct 18;36(11):2824-2839. doi: 10.1093/humrep/deab206.
Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Furthermore, we emphasize the importance of artificial intelligence in analyzing liquid biopsy data with the aim of developing ethically-responsible non-invasive technologies that can enhance individualized healthcare. While previous reviews have mainly focused on cancer, this review primarily highlights applications of liquid biopsy in reproductive medicine.
液体活检是一种采样和分析体液的过程，可实现对体内复杂生物系统的非侵入性监测。液体活检在健康和疾病中有广泛的应用，因为可以分析各种各样的成分，包括循环细胞到无细胞核酸分子。在这里，我们回顾了液体活检的不同成分，调查了用于检测这些成分的最新、非侵入性方法，展示了它们的临床应用，并讨论了伦理考虑。此外，我们强调了人工智能在分析液体活检数据中的重要性，旨在开发负责任的非侵入性技术，以增强个体化医疗。虽然之前的综述主要集中在癌症上，但本篇综述主要强调了液体活检在生殖医学中的应用。
