Meyer Thibault, Thiour-Mauprivez Clémence, Wisniewski-Dyé Florence, Kerzaon Isabelle, Comte Gilles, Vial Ludovic, Lavire Céline
UMR Ecologie Microbienne, CNRS, INRA, VetAgro Sup, UCBL, Université de Lyon, Lyon, France.
Biocapteurs-Analyses-Environment, Universite de Perpignan Via Domitia, Perpignan, France.
Front Plant Sci. 2019 Jul 30;10:978. doi: 10.3389/fpls.2019.00978. eCollection 2019.
The study of pathogenic agents in their natural niches allows for a better understanding of disease persistence and dissemination. Bacteria belonging to the genus are soil-borne and can colonize the rhizosphere. These bacteria are also well known as phytopathogens as they can cause tumors (crown gall disease) by transferring a DNA region (T-DNA) into a wide range of plants. Most reviews on are focused on virulence determinants, T-DNA integration, bacterial and plant factors influencing the efficiency of genetic transformation. Recent research papers have focused on the plant tumor environment on the one hand, and genetic traits potentially involved in bacterium-plant interactions on the other hand. The present review gathers current knowledge about the special conditions encountered in the tumor environment along with the genetic determinants putatively involved in bacterial persistence inside a tumor. By integrating recent metabolomic and transcriptomic studies, we describe how tumors develop and how can maintain itself in this nutrient-rich but stressful and competitive environment.
对病原体在其自然生态位中的研究有助于更好地理解疾病的持续存在和传播。属于该属的细菌是土壤传播的，能够在根际定殖。这些细菌也因其能通过将一个DNA区域（T-DNA）转移到多种植物中而导致肿瘤（冠瘿病）而广为人知。大多数关于……的综述都集中在毒力决定因素、T-DNA整合、影响遗传转化效率的细菌和植物因素上。最近的研究论文一方面关注植物肿瘤环境，另一方面关注可能参与细菌与植物相互作用的遗传特性。本综述汇集了关于肿瘤环境中遇到的特殊条件以及推测参与肿瘤内细菌持续存在的遗传决定因素的现有知识。通过整合最近的代谢组学和转录组学研究，我们描述了肿瘤如何发展以及……如何在这个营养丰富但压力大且竞争激烈的环境中维持自身。
