Hajshafiha Masoumeh, Behrouzi Lak Tahere, Hajiloo Nasrin, Deldar Yaghoub, Ghorbani Mina, Haghollahi Fedyeh
Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Motahary Hospital, Urmia University of Medical Sciences, Urmia, Iran.
Int J Reprod Biomed. 2019 Jan 28;16(12). doi: 10.18502/ijrm.v16i12.3686. eCollection 2018 Dec.
The failure to retrieve oocytes from mature ovarian follicles is referred to as empty follicle syndrome. There is no exact explanation to this problem and it cannot be predicted using ultrasound or serum hormonal levels. The underlying mechanism of Empty follicle syndrome remains obscure.
In this study, the authors have investigated the relationship between the Beta-Human chorionic gonadotropin ( HCG) levels in the follicular fluid with or without the oocyte in the follicles of patients undergoing Intracytoplasmic Sperm Injection.
Seventy-three infertile couples underwent standard long protocol induction ovulation for Intracytoplasmic sperm injection. On the day of oocyte retrieval, each patient had two samples; follicular fluid including 2-3 follicles with oocyte and follicular fluid including of 2-3 follicles without oocyte were collected in separate tubes. These follicles had similar shape and size. The Samples were transferred to a laboratory for measuring the HCG level, after which the HCG levels were compared to the follicles with and without the oocyte in each patient.
In this study, the HCG level of follicular fluid in the follicles containing oocyte was 18.20 (8.35-42.92) IU/L and in the follicles without the oocyte was 13.50 (5.45-25.81) IU/L. Levels of HCG in the follicular fluids containing the oocyte were higher than without oocytes, This difference was not statistically significant ( = 0.16).
It seems that the follicular fluid HCG isn't caused by empty follicle syndrome, and that dysfunctional folliculogenesis may be the cause of this syndrome.
从成熟卵巢卵泡中未能获取到卵母细胞被称为空卵泡综合征。对此问题尚无确切解释，且无法通过超声或血清激素水平进行预测。空卵泡综合征的潜在机制仍不清楚。
在本研究中，作者调查了接受卵胞浆内单精子注射患者卵泡中有无卵母细胞时卵泡液中β-人绒毛膜促性腺激素（HCG）水平之间的关系。
73对不孕夫妇接受标准长方案诱导排卵以进行卵胞浆内单精子注射。在取卵当天，每位患者有两份样本；分别收集含有2 - 3个有卵母细胞卵泡的卵泡液和含有2 - 3个无卵母细胞卵泡的卵泡液，将其置于不同试管中。这些卵泡具有相似的形状和大小。样本被转移至实验室测量HCG水平，之后将每位患者有卵母细胞和无卵母细胞卵泡的HCG水平进行比较。
在本研究中，含有卵母细胞卵泡的卵泡液HCG水平为18.20（8.35 - 42.92）IU/L，无卵母细胞卵泡的卵泡液HCG水平为13.50（5.45 - 25.81）IU/L。含有卵母细胞的卵泡液中HCG水平高于无卵母细胞的卵泡液，但这种差异无统计学意义（P = 0.16）。
似乎卵泡液HCG并非由空卵泡综合征引起，卵泡发生功能障碍可能是该综合征的原因。
