Jeroen Bosch Ziekenhuis, Henri Dunantstraat 1, 5223 GZ's-Hertogenbosch, The Netherlands, Tel.: 06-42 846781.
Jeroen Bosch Ziekenhuis, Henri Dunantstraat 1, 5223 GZ's-Hertogenbosch, The Netherlands.
J Perinat Med. 2019 Sep 25;47(7):780-784. doi: 10.1515/jpm-2019-0004.
Background Smoking during pregnancy still exists in daily life but the effect on the newborn in the early stage of life is still unclear. This study investigates the normal reference range of carboxyhemoglobin (HbCO) in umbilical cord blood gas (UBG). Methods A single center retrospective cross-sectional cohort study was performed with 1172 cases. We analyzed HbCO values in umbilical cord blood, maternal smoking, birth weight percentiles, duration of amenorrhea and maternal admission duration prior to delivery. Results HbCO levels in newborns range from 0 to 7.7% with a mean of 0.6% (standard deviation 0.6). Newborns from women who smoked during pregnancy have a significant higher HbCO value compared to newborns from women who did not smoke. Birth weight is negatively correlated with HbCO (P = 0.001). Conclusion Our results show the normal reference range in this study is 0-1.2% for HbCO in the umbilical blood of newborns. Smoking prior to delivery leads to a higher HbCO value in the UBG sample of the newborn, a lower birth weight and may be potential harmful.
背景
怀孕期间吸烟在日常生活中仍然存在，但对新生儿生命早期的影响尚不清楚。本研究旨在探讨脐带血气（UBG）中碳氧血红蛋白（HbCO）的正常参考范围。
方法
采用单中心回顾性队列研究，共纳入 1172 例病例。我们分析了脐带血中 HbCO 值、孕妇吸烟情况、出生体重百分位数、闭经时间和分娩前产妇住院时间。
结果
新生儿的 HbCO 水平范围为 0 至 7.7%，平均值为 0.6%（标准差为 0.6）。与不吸烟孕妇所生的新生儿相比，吸烟孕妇所生的新生儿的 HbCO 值显著更高。出生体重与 HbCO 呈负相关（P=0.001）。
结论
本研究结果显示，新生儿脐带血 HbCO 的正常参考范围为 0-1.2%。分娩前吸烟会导致新生儿 UBG 样本中的 HbCO 值升高、出生体重降低，可能存在潜在危害。
