Departmento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/ Virgen de África, 7, E-41011 Sevilla, Spain.
Departmento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/ Virgen de África, 7, E-41011 Sevilla, Spain.
Sci Total Environ. 2019 Dec 10;695:133864. doi: 10.1016/j.scitotenv.2019.133864. Epub 2019 Aug 11.
Population is continuously exposed to endocrine disrupting compounds present in everyday products such as parabens, bisphenol A (BPA), and perfluoroalkyl compounds (PFCs). The aims of this study were, first, to evaluate human exposure to three parabens (methylparaben (MeP), ethylparaben (EtP) and propylparaben (PrP)), BPA and six PFCs (perfluorobutanoic acid, perfluoropentanoic acid, perfluorohexanoic acid, perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS)) through the analysis of hair samples from children, women and men and, then, to evaluate possible relationships between pollutant concentration in hair and age, gender, smoking and dyeing habits or hair colour. Hair samples were collected from 42 volunteers from Seville (Spain) (10 children, 16 women and 16 men). Six of the monitored pollutants (MeP, EtP, PrP, BPA, PFHpA and PFOS) were detected in at least 76% of the samples analysed. The highest concentrations and frequency of detection (100% of the samples) corresponded to MeP and PrP (up to 14,187 and 9009 ng/g, respectively). BPA was found in 83% of the samples at concentrations in the range from 24 to 1427 ng/g whereas PFCs were detected at concentrations in the range from 0.6 to 15.5 ng/g, being PFHpA and PFOS the ones most frequently detected (86% and 76%, respectively). Concentrations of BPA and parabens in adults were statistically higher than those in children. The results of this study reveal the suitability of hair for biomonitoring endocrine disrupting compounds of high concern (PFCs, parabens and BPA) to which population is internally or/and externally but continuously exposed.
人口不断接触到日常生活用品中存在的内分泌干扰化合物，如对羟基苯甲酸酯、双酚 A (BPA) 和全氟烷基化合物 (PFCs)。本研究的目的首先是评估儿童、妇女和男性头发样本中三种对羟基苯甲酸酯（对羟基苯甲酸甲酯 (MeP)、对羟基苯甲酸乙酯 (EtP) 和对羟基苯甲酸丙酯 (PrP)）、BPA 和六种 PFCs（全氟丁酸、全氟戊酸、全氟己酸、全氟庚酸 (PFHpA)、全氟辛酸 (PFOA) 和全氟辛烷磺酸 (PFOS)）的暴露情况，然后评估污染物在头发中的浓度与年龄、性别、吸烟和染发习惯或头发颜色之间的可能关系。头发样本来自西班牙塞维利亚的 42 名志愿者（10 名儿童、16 名妇女和 16 名男性）。在分析的至少 76%的样本中检测到了其中六种监测污染物（MeP、EtP、PrP、BPA、PFHpA 和 PFOS）。浓度最高且检出频率最高的是 MeP 和 PrP（分别高达 14187 和 9009ng/g）。BPA 在 83%的样本中被检出，浓度范围为 24 至 1427ng/g，而 PFCs 的浓度范围为 0.6 至 15.5ng/g，其中 PFHpA 和 PFOS 是最常被检出的（分别为 86%和 76%）。成年人的 BPA 和对羟基苯甲酸酯浓度明显高于儿童。本研究结果表明，头发适合用于生物监测高关注内分泌干扰化合物（PFCs、对羟基苯甲酸酯和 BPA），这些化合物不断地通过内部或/和外部途径暴露于人群中。
