用于癌症治疗的血管去分化
Vascular Detransformation for Cancer Therapy.
作者信息
Fan Yi
机构信息
Departments of Radiation Oncology and Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Trends Cancer. 2019 Aug;5(8):460-463. doi: 10.1016/j.trecan.2019.05.007. Epub 2019 Jun 14.
Abstract
Angiogenesis is a hallmark of cancer. However, current antivascular therapies that primarily target angiogenic factors have faced difficulties and failures in treating most cancers. It is proposed that endothelial transformation acts as an alternative driver of excessive and abnormal vascularity that fuels cancer progression and immunosuppression, and also induces resistance to therapy. Thus, vascular detransformation may serve as a promising therapeutic strategy against cancer.
摘要
血管生成是癌症的一个标志。然而，目前主要针对血管生成因子的抗血管生成疗法在治疗大多数癌症时面临困难和失败。有人提出，内皮细胞转变是过度和异常血管生成的另一种驱动因素，这种血管生成促进癌症进展和免疫抑制，还会诱导对治疗的抗性。因此，血管去转变可能成为一种有前景的抗癌治疗策略。
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