Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Trends Endocrinol Metab. 2019 Oct;30(10):710-723. doi: 10.1016/j.tem.2019.07.020. Epub 2019 Aug 16.
The global prevalence of obesity continues to increase, suggesting a need for alternative treatment approaches. Targeting brown fat function to promote energy expenditure represents one such approach. Brown adipocytes and the related beige adipocytes oxidize fatty acids and glucose to generate heat and are activated by cold exposure or consumption of high-calorie diets. Alternative, more practical means to activate thermogenic fat are needed. Here, we review emerging data suggesting new roles for lipids in activating thermogenesis that extend beyond their serving as a fuel source for heat generation. Lipids have also been implicated in mediating interorgan communication, crosstalk between organelles, and cellular signaling regulating thermogenesis. Understanding how lipids regulate thermogenesis could identify innovative therapeutic interventions for obesity.
全球肥胖症的患病率持续上升，这表明需要寻找替代的治疗方法。针对棕色脂肪功能以促进能量消耗就是一种这样的方法。棕色脂肪细胞和相关的米色脂肪细胞氧化脂肪酸和葡萄糖以产生热量，并通过暴露于寒冷或摄入高热量饮食而被激活。需要寻找替代的、更实用的方法来激活产热脂肪。在这里，我们回顾了一些新出现的数据，这些数据表明脂质在激活产热方面有新的作用，超出了它们作为热量产生的燃料来源的作用。脂质还被牵涉到介导器官间通讯、细胞器间的串扰以及调节产热的细胞信号转导中。了解脂质如何调节产热可以为肥胖症确定创新的治疗干预措施。
