脂肪组织中冷激活脂质动力学凸显了心磷脂在产热代谢中的作用。
Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism.
机构信息
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
出版信息
Cell Rep. 2018 Jul 17;24(3):781-790. doi: 10.1016/j.celrep.2018.06.073.
Abstract
Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MS shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure.
摘要
产热脂肪在寒冷时为维持体温稳定而消耗能量，其活性调节营养代谢和胰岛素敏感性。我们通过 MS/MS shotgun 脂质组学测量了循环和脂肪组织中冷激活的脂质图谱。我们创建了一个交互式在线查看器，以可视化特定脂质种类对冷刺激的反应变化。在脂肪组织中，在大约 1600 种脂质种类中，我们确定了线粒体磷脂心磷脂的生物合成途径，作为野生型和转基因小鼠白色脂肪增强棕色化时冷刺激下棕色和米色脂肪中协调激活的途径。总之，这些数据提供了循环和组织中产热脂肪激活的综合脂质生物特征，并提示了冷暴露调节的途径。
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本文引用的文献
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Cell Metab. 2018 Jul 3;28(1):159-174.e11. doi: 10.1016/j.cmet.2018.05.003. Epub 2018 May 31.
2
Adapted MS/MS Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species.用于分析心磷脂分子种类的改良型串联质谱鸟枪法脂质组学方法
Lipids. 2018 Jan;53(1):133-142. doi: 10.1002/lipd.12004.
3
Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue.冷诱导产热依赖于心肌中的 ATGL 介导的脂解作用，但不依赖于棕色脂肪组织。
Cell Metab. 2017 Nov 7;26(5):753-763.e7. doi: 10.1016/j.cmet.2017.09.004. Epub 2017 Oct 5.
4
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.全球血浆脂质分析鉴定肝衍生酰基辅酶 A 作为棕色脂肪产热的燃料来源
Cell Metab. 2017 Sep 5;26(3):509-522.e6. doi: 10.1016/j.cmet.2017.08.006.
5
Deciphering adipose tissue heterogeneity.解析脂肪组织异质性。
Ann N Y Acad Sci. 2018 Jan;1411(1):5-20. doi: 10.1111/nyas.13398. Epub 2017 Aug 1.
6
The early metabolomic response of adipose tissue during acute cold exposure in mice.急性冷暴露小鼠脂肪组织的早期代谢组学反应。
Sci Rep. 2017 Jun 14;7(1):3455. doi: 10.1038/s41598-017-03108-x.
7
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9
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10
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Biochimie. 2017 Mar;134:71-76. doi: 10.1016/j.biochi.2016.09.008. Epub 2016 Sep 10.
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